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Purine nucleoside phosphorylase deficiency associated with a fatal lymphoproliferative disorder.
  1. A R Watson,
  2. D I Evans,
  3. H B Marsden,
  4. V Miller,
  5. P A Rogers


    A 2 1/2-year-old boy presented with an illness resembling glandular fever. He was found to have T-cell deficiency with lack of red and white cell purine nucleoside phosphorylase enzyme activity. A spastic tetraparesis was noted. The patient subsequently died of a malignant lymphoma of the B-immunoblastic type.

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