Abstract

26 children with meningococcal infections were studied to find out the relationaship between plasma and cerebrospinal fluid levels of endotoxin, the clinical outcome, the level of antigen in plasma and cerebrospinal fluid, and indices of complement activation and disseminated intravascular coagulation. No association was found between endotoxin levels and the other factors. A high cerebrospinal fluid antigen level in patients with meningitis was associated with a poor prognosis.