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Chloramphenicol and phenobarbitone--a drug interaction.
  1. R A Bloxham,
  2. G M Durbin,
  3. T Johnson,
  4. M H Winterborn


    Two infants with meningitis who were treated with phenobarbitone and high-dose chloramphenicol showed progressive falls in the peak blood levels of chloramphenicol. A standard chloramphenicol dose of 50 mg/kg daily would have produced subtherapeutic blood levels after only a few days. The importance of measuring serial blood chloramphenicol concentrations is stressed.

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