105 blood samples from 72 infants, mostly with jaundice due to haemolytic disease, were analysed for reserve albumin binding capacity (HBABA method), salicylate saturation index (SI), and red cell binding of bilirubin. 2 infants with clinical symptoms of bilirubin encephalopathy had abnormally large amounts of red cell bound bilirubin, though the HBABA binding capacity and salicylate saturation index did not suggest a risk of bilirubin encephalopathy. On the other hand, 48 of the other samples showed `risk values' for saturation index and 2 of the other samples showed such values as judged by the HBABA method. The discrepancies between these findings are discussed. It is suggested that determination of red cell bound bilirubin may have clinical value in patients with neonatal jaundice, especially in cases of suggested kernicterus.
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