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Familial Occurrence of Letterer-Siwe Disease
  1. Emil Freundlich,
  2. Sarah Amit,
  3. Yohan Montag,
  4. Harry Suprun,
  5. Sarah Nevo


    Letterer-Siwe disease occurred in 4 infant sibs from two consanguineous families. An identical clinical course and pathological picture was observed in all 4 infants.

    The occurrence of families with multiple cases supports the hypothesis of genetic causation in Letterer-Siwe disease. The family patterns are in accord with an autosomal recessive inheritance.

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