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Syndrome of Growth Resistance, Obesity, and Intellectual Impairment with Precocious Puberty
  1. Duncan R. Macmillan,
  2. Chong Bin Kim,
  3. Bernard Weisskopf


    A syndrome of growth resistance, obesity, and intellectual impairment with precocious puberty is described. Two girls presenting with many of the manifestations of the Prader-Willi syndrome, including growth resistance, obesity, and intellectual impairment, also exhibited precocious sexual maturation. It is suggested that this syndrome represents a hypothalamic disturbance closely related to the Prader-Willi syndrome and should be considered one of its variants.

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