Article Text

Download PDFPDF
Immunoconglutinin and Complement Studies in Congenital Nephrotic Syndrome and Nephritis of Henoch-Schönlein Purpura in Children
  1. S. T. Shulman,
  2. T. M. Barratt,
  3. J. F. Soothill


    Evidence of complement activation in 6 children with congenital nephrotic syndrome and 9 children with nephritis associated with Henoch-Schönlein purpura was sought by estimating the concentration and by immunoelectrophoretic analysis of the complement component C3, and by immunoconglutinin titration (IK: an autoantibody to reacted complement components). IK and quantitative C3 levels did not differ significantly from control values in either disease; in vivo C3 conversion was not detected in plasma from congenital nephrotic patients, but was present in 2 of 9 patients with Henoch-Schönlein nephritis. The data do not provide consistent evidence of complement involvement in either disease.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.