The effect of altering peak airway pressure, respiratory frequency, and inspiration: expiration ratio on arterial blood gas tensions, blood pressure, and calculated right-to-left shunt was investigated in 6 infants undergoing mechanical ventilation for hyaline membrane disease with a Bennet ventilator. The use of a very long inspiratory phase resulted in a large increase in Pao2 and fall in right-to-left shunt without affecting mean arterial blood pressure.
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