A 2-year-old-girl with severe bicarbonate-losing renal tubular acidosis was treated successively with bicarbonate, THAM, and two diuretics, hydrochlorothiazide and frusemide. Only with hydrochlorothiazide was adequate correction of the acid-base balance achieved. The relative importance of changes induced by this treatment in the extracellular fluid volume and in chloride depletion was assessed.
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