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Immune Deficiency State in a Girl with Eczema and Low Serum IgM
  1. D. I. K. Evans,
  2. A. Holzel

    Possible Female Variant of Wiskott-Aldrich Syndrome


    This report concerns an immune deficiency disorder in a girl with eczema. She has had recurrent infections including three severe attacks of herpes simplex and five attacks of pneumococcal meningitis. There is a moderate lymphopenia, dysgammaglobulinaemia with high IgG, high IgA, and low IgM; lymphocyte transformation with phytohaemagglutinin is impaired. Production of circulating antibody is abnormal, as are delayed hypersensitivity reactions. Although there is no thrombocytopenia, the resemblance to the Wiskott-Aldrich syndrome is discussed.

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    Possible Female Variant of Wiskott-Aldrich Syndrome