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Eosinophilic oesophagitis – have we caused it?

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Over the last decade, the incidence of eosinophilic oesophagitis (EoE) appears to have increased. In genetically predisposed individuals, the evidence seems to suggest an early life exposure or event that has initiated this lower oesophageal morbidity. What factors could contribute to this? Jensen at al (JAMA Pediatr. 2023;177:1285–1293. doi:10.1001/jamapediatrics.2023.4609) have examined the association between antibiotic use in pregnancy and in early infancy and the role of acid suppressants during infancy. This was a large case-controlled study from Scandinavia and included 392 cases of EoE with comparison to 3637 controls. The authors examined this population-based data from an inpatient and outpatient …

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