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Vulval (Lipschütz) ulcers in young females associated with SARS-CoV-2 infection and COVID-19 vaccination: case series
  1. Victoria Litza Crofts1,
  2. Hazel J Clothier2,3,4,
  3. John Mallard2,4,
  4. Jim P Buttery2,4,5,
  5. Sonia R Grover1
  1. 1 Paediatric and Adolescent Gynaecology, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
  2. 2 SAEFVIC, Murdoch Children’s Research Institute, Melbourne, Victoria, Australia
  3. 3 School of Population & Global Health, University of Melbourne, Melbourne, Victoria, Australia
  4. 4 Child Health Analytics, Melbourne Children’s Campus, Parkville, Victoria, Australia
  5. 5 Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia
  1. Correspondence to Dr Victoria Litza Crofts, The Royal Children's Hospital Melbourne, Parkville, VIC 3052, Australia; victoria.crofts{at}

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Recent case reports have raised the possible association between Lipschütz ulcers and either SARS-CoV-2 infection or COVID-19 vaccination. A brief literature review of female genital mucosal lesions associated with COVID-19 vaccination was recently published.1 We report the largest case series to date to further demonstrate this association.

Cases were identified from a search of all 65 633 reports (44 870 following COVID-19 vaccines and 20 788 other vaccines) submitted to Victoria’s adverse event following immunisation (AEFI) surveillance service, SAEFVIC from May 2007 (commencement) to 31 August 2022 and from referrals and emergency department presentations to Royal Children’s Hospital (RCH) from January 2015 (beginning of informatised medical file) to December 2022. Data collected included age, sexual activity, time of onset of symptoms after infection/vaccination, clinical findings, results, management and outcome.

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  • Contributors VLC author HJC coauthor. JM collected data. JB critically reviewed the manuscript. SG critically reviewed the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.