Footnotes

• Contributors A Connery, A Colbert and ML contributed to the ideas in the paper, as well as the writing and the research. They have collaborated on previous research at our research and clinic site that have led to the ideas put forth in the paper.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests None declared.

• Provenance and peer review Not commissioned; externally peer reviewed.