• Sepsis

The Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS) study has been published. This is an adult-study, so of course cannot be directly extrapolated into the paediatric world, we know that there are different co-morbidities and physiological responses to shock in adults compared with children, but it involves an important question for paediatrics. A question the paediatric world is having difficulties addressing since the publication of the FEAST study which questioned liberal use of fluids in resuscitation in children in shock (Maitland K et al, N Engl J Med 2011;364:2483–2495). In another example of using huge networks to recruit sufficient …