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Paediatric hospital antimicrobial guidelines: a national UK review
  1. Annalie Shears1,2,
  2. Lucy Hoskyns1,
  3. Paul Flinders1,
  4. Rebeka Conry1,
  5. Paddy McMaster1,3
  6. UK-PAS Committee
    1. 1 Paediatrics, Royal Manchester Children's Hospital, Manchester, UK
    2. 2 Paediatrics, The University of Manchester, Manchester, UK
    3. 3 Paediatrics, North Manchester General Hospital, Manchester, UK
    4. 4 UK Paediatric Antimicrobial Stewardship Committee, Manchester, UK
    1. Correspondence to Dr Annalie Shears, Paediatrics, Royal Manchester Children's Hospital, Manchester M13 9WL, UK; annalieshears{at}

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    Paediatric inpatient antimicrobial prescribing is frequently inappropriate and varies markedly and unnecessarily across the UK between tertiary centres, district general hospitals and even between clinicians in individual hospitals.1 Antimicrobial guidelines have been frequently mentioned by clinicians in the UK as informing paediatric antibiotic prescribing practice.2 Guidelines are more likely to be used by clinicians if they are evidence based, rigorously produced and shown to improve outcomes.3 The UK Paediatric Antimicrobial Stewardship (UK-PAS) network therefore aims to reach national consensus by publishing an antimicrobial summary for hospitals with nationwide input from paediatric infectious disease (PID) experts. However, little is known about the current nature and quality of paediatric antimicrobial guidelines across the UK.

    National Health Service (NHS) trusts in England, Wales, Scotland and Northern Ireland responsible for the …

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    • Collaborators UK Paediatric Antimicrobial Stewardship Committee: Sam Channon-Wells, Alicia Demirjian, Katja Doerholt, Simon Drysdale, James Hatcher, Avni Hindocha, Marieke Emonts, Sanjay Patel, Aisling Rafferty, Laura Ferras-Antolin, Ashifa Trivedi, Stefania Vergano, Anita Verma.

    • Contributors AS, LH, PF and RC independently reviewed the guidelines discussed in this paper. AS, PM and LH contributed to the writing of the manuscript on behalf of and with the permission of the UK-PAS Committee. UK-PAS Committee members SC-W, AD, KD, SD, JH, AH, ME, SP, AR, LF-A, AT, SV and AV reviewed and provided comments on the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.