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The Fluid Expansion As Supportive Therapy (FEAST) study demonstrated a 45% relative increased risk of mortality with fluid bolus (with albumin or saline) compared with nonbolus controls (95% CI, 1.13 to 1.86; p=0.003) in children with septic shock in settings where there was no access to intensive care facilities [Maitland K et al. N Engl J Med 2011; 364:2483–2495]. This certainly challenged traditional views on fluid resuscitation in septic shock and international guidelines have been influenced by these findings, suggesting a more conservative approach where intensive care is not available. In a small but detailed, …
Provenance and peer review Commissioned; internally peer reviewed.