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Vitamin D deficiency (VDD) is a perennial problem in the UK.
The Royal Osteoporosis Society (ROS) guideline for treatment of VDD, defined as 25-hydroxyvitamin D (25-OHD) <25 nmol/L, is1:
1–5 months: 3000 international units (IU)/day for 8–12 weeks;
6 months to 11 years: 6000 IU/day for 8–12 weeks
≥12 years: 10 000 IU/d for 8–12 weeks
alternative ≥12 years: 300 000 IU/day total in single or divided dose
This is supported by the British Society of Paediatric Endocrinology and Diabetes and the RCPCH vitamin D resource page.
We planned to determine whether treatment resulted in an increase in serum 25-OHD to over 50 nmol/L and how this related to dose/kg.
A retrospective review of consecutive patient records referred to our paediatric bone …
Contributors PA devised the project. FA collected the data. FA analysed the data with input from PA, NB and SB. FA wrote the manuscript with input from all authors.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.