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Should we use weight-based vitamin D treatment in children?
  1. Fawaz Arshad1,2,
  2. Paul Arundel3,
  3. Nicholas Bishop2,3,
  4. Stephanie Borg2,3
  1. 1 Sheffield Children's NHS Foundation Trust, Sheffield, UK
  2. 2 Department of Oncology and Metabolism, The University of Sheffield, Sheffield, UK
  3. 3 Metabolic Bone Team, Sheffield Children's NHS Foundation Trust, Sheffield, UK
  1. Correspondence to Dr Fawaz Arshad, Sheffield Children's NHS Foundation Trust, Sheffield, UK; fawaz.arshad{at}

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Vitamin D deficiency (VDD) is a perennial problem in the UK.

The Royal Osteoporosis Society (ROS) guideline for treatment of VDD, defined as 25-hydroxyvitamin D (25-OHD) <25 nmol/L, is1:

  • 1–5 months: 3000 international units (IU)/day for 8–12 weeks;

  • 6 months to 11 years: 6000 IU/day for 8–12 weeks

  • ≥12 years: 10 000 IU/d for 8–12 weeks

  • alternative ≥12 years: 300 000 IU/day total in single or divided dose

This is supported by the British Society of Paediatric Endocrinology and Diabetes and the RCPCH vitamin D resource page.

We planned to determine whether treatment resulted in an increase in serum 25-OHD to over 50 nmol/L and how this related to dose/kg.

A retrospective review of consecutive patient records referred to our paediatric bone …

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  • Contributors PA devised the project. FA collected the data. FA analysed the data with input from PA, NB and SB. FA wrote the manuscript with input from all authors.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.