May 2022 - Volume 107 - 5
Clinical law for clinical practice
Global child health
- Pertussis seroprevalence in mother–infant pairs from India: role of maternal immunisation (15 September, 2021)
This observational study showed that in one location in India, pertussis immunity among pregnant women was low (12%) pertussis immunization in early pregnancy resulted in a higher proportion (54%) of mothers and newborns with pertussis antibodies at a protective level. The appropriate timing of maternal immunization is discussed.
- Barriers to seeking timely treatment for severe childhood pneumonia in rural Bangladesh (15 September, 2021)
Lower respiratory illness remains the largest cause of mortality for children under 5 worldwide. Early intervention and care can be profoundly lifesaving, but significant barriers to seeking care remain. In this qualitative study, several are identified among Bangladeshi mothers.
- Qualitative assessment of caustic soda injury in Liberia (8 November, 2021)
Caustic sodas such as lye are a significant cause of morbidity and mortality throughout the world this qualitative analysis provides some insights.
- Is the NICE traffic light system fit-for-purpose for children presenting with undifferentiated acute illness in primary care? (21 September, 2021)
Secondary analysis of participants from the DUTY study. Assesses performance of NICE guidance. Included 6,797 children under fives 94% were amber or red i.e. needing referral to secondary care Demonstrates that NICE traffic light tool not useful in primary care
- Friedreich’s ataxia-associated childhood hypertrophic cardiomyopathy: a national cohort study (5 October, 2021)
In the largest cohort of children with Hypertrophic Cardiomyopathy associated with Friedrich's Ataxia presented to date a surprisingly high prevalence of atrial arrhythmias are described, and a reminder of the need for serial cardiac screening in these children is reinforced.
- Description and evaluation of a pathway for unaccompanied asylum-seeking children (16 October, 2021)
A study in a clinic for unaccompanied asylum seeking children (UASC) in a single London borough demonstrates a high level of variable needs and pathology. Many of the children had endured physical and sexual abuse and torture. An integrated multidisciplinary pathway is proposed.
- Looking beyond: complex holistic care needs of Syrian and Iraqi refugee children and adolescents (26 October, 2021)
A cross sectional observational study of multidisciplinary assessment of Syrian and Iraqi child refugees in Australia, showing multiple complex health concerns across physical, psychosocial and developmental/educational domains.
- Secular trends in early motor development between 1980 and 2010 in Japan (5 November, 2021)
A survey in Japan from 1980 to 2010 examined achievement of defined motor milestones. The ages of sitting, standing and walking increased over time. The reasons are unclear and may relate to adaptation to modern life with priority of abstract thinking over motor skills
- Priorities for child health research across the UK and Ireland (29 October, 2021)
To improve the management of general paediatric conditions we need better research this paper outlines the unanswered topics most important to parent representatives and paediatricians.
- Treating nontuberculous mycobacteria in children with cystic fibrosis: a multicentre retrospective study (5 November, 2021)
Data from 11 cystic fibrosis centres in UK with clinical information on 70 subjects examining nontuberculous mycobacterium (NTM) were collated (60 Mycobacterium abscessus complex (MABSC) 10 M. avium complex (MAC)). Older age and previous diagnosis of allergic bronchopulmonary aspergillosis were all with NTM. There was a wide variance in drug choice and side effects were reported with all agents. NTM eradication occurred in 80% of patients with MAC and 48% with MABSC, with variable outcomes on lung function. Large multi centre studies are required.
- Non-collagen pathogenic variants resulting in the osteogenesis imperfecta phenotype in children: a single-country observational cohort study (8 November, 2021)
Important observational cohort on OI - looking at genetic variants.
- Paediatric pneumonia: deriving a model to identify severe disease (10 November, 2021)
The trajectory after admission in children with community acquired pneumonia is unpredictable. This derivation study based on 3,000 episodes, provides data to guide risk scoring.
- BReATHE interventions (Beating Regional Asthma Through Health Education)—an innovative approach to children’s asthma care in the North East and North Cumbria, UK: an interventional study (7 October, 2021)
In this quality improvement report, multiple interventions aimed at promoting health professionals’ adherence to national guidelines and supporting patient self management through improved patient education, resulted in a significant and sustained reduction in unscheduled paediatric asthma admissions.