Table of contents

May 2022 - Volume 107 - 5



  • The climate crisis is also a child rights crisis (7 December, 2021)
    Haytham Ali, Alison Firth, Alison Leaf, Cinthu Vivehananthan, Dhurgshaarna Shanmugavadivel, Ekundayo Ajayi-Obe, Jay Halbert, Jenny Harper Gow, Mia Thomas, Paula de Sousa, Tony Waterston, Bernadette O'Hare

Clinical law for clinical practice


Global child health

  • Pertussis seroprevalence in mother–infant pairs from India: role of maternal immunisation (15 September, 2021)
    Rajlakshmi Viswanathan, Sanjay Bafna, Kalyani Patil, Santoshkumar Jadhav, Savita Katendra, Shweta Mishra, Shradha Maheshwari, Hemant Damle

    This observational study showed that in one location in India, pertussis immunity among pregnant women was low (12%) pertussis immunization in early pregnancy resulted in a higher proportion (54%) of mothers and newborns with pertussis antibodies at a protective level. The appropriate timing of maternal immunization is discussed.

  • Barriers to seeking timely treatment for severe childhood pneumonia in rural Bangladesh (15 September, 2021)
    Kamal Ibne Amin Chowdhury, Ishrat Jabeen, Mahfuzur Rahman, Abu Syed Golam Faruque, Nur H Alam, Shahjahan Ali, Tahmeed Ahmed, George J Fuchs, Trevor Duke, Niklaus Gyr, Haribondhu Sarma

    Lower respiratory illness remains the largest cause of mortality for children under 5 worldwide. Early intervention and care can be profoundly lifesaving, but significant barriers to seeking care remain. In this qualitative study, several are identified among Bangladeshi mothers.

  • Qualitative assessment of caustic soda injury in Liberia (8 November, 2021) Free
    Jethro Zawolo, Keri A Cohn, Maima Kawah-Baysah, Salome Weah-Chenoway, Lawuobah Gbozee, Alexandra M Vinograd

    Caustic sodas such as lye are a significant cause of morbidity and mortality throughout the world this qualitative analysis provides some insights.

Original research

  • Is the NICE traffic light system fit-for-purpose for children presenting with undifferentiated acute illness in primary care? (21 September, 2021)
    Megan Hedd Blyth, Rebecca Cannings-John, Alastair D Hay, Christopher C Butler, Kathryn Hughes

    Secondary analysis of participants from the DUTY study. Assesses performance of NICE guidance. Included 6,797 children under fives 94% were amber or red i.e. needing referral to secondary care Demonstrates that NICE traffic light tool not useful in primary care

  • Friedreich’s ataxia-associated childhood hypertrophic cardiomyopathy: a national cohort study (5 October, 2021)
    Gabrielle Norrish, Thomas Rance, Elena Montanes, Ella Field, Elspeth Brown, Vinay Bhole, Graham Stuart, Orhan Uzun, Karen A McLeod, Maria Ilina, Satish Adwani, Piers Daubeney, Grazia Delle Donne, Katie Linter, Caroline B Jones, Tara Bharucha, Elena Cervi, Juan Pablo Kaski

    In the largest cohort of children with Hypertrophic Cardiomyopathy associated with Friedrich's Ataxia presented to date a surprisingly high prevalence of atrial arrhythmias are described, and a reminder of the need for serial cardiac screening in these children is reinforced.

  • Description and evaluation of a pathway for unaccompanied asylum-seeking children (16 October, 2021)
    Alice Jane Armitage, Jonathan Cohen, Michelle Heys, Pia Hardelid, Allison Ward, Sarah Eisen

    A study in a clinic for unaccompanied asylum seeking children (UASC) in a single London borough demonstrates a high level of variable needs and pathology. Many of the children had endured physical and sexual abuse and torture. An integrated multidisciplinary pathway is proposed.

  • Looking beyond: complex holistic care needs of Syrian and Iraqi refugee children and adolescents (26 October, 2021)
    Kristen Lindsay, Gemma Hanes, Raewyn Mutch, Elizabeth McKinnon, Sarah Cherian

    A cross sectional observational study of multidisciplinary assessment of Syrian and Iraqi child refugees in Australia, showing multiple complex health concerns across physical, psychosocial and developmental/educational domains.

  • Secular trends in early motor development between 1980 and 2010 in Japan (5 November, 2021)
    Keisuke Yoshii, Nobuaki Michihata, Kyoko Hirasawa, Satoru Nagata, Naho Morisaki

    A survey in Japan from 1980 to 2010 examined achievement of defined motor milestones. The ages of sitting, standing and walking increased over time. The reasons are unclear and may relate to adaptation to modern life with priority of abstract thinking over motor skills

  • Priorities for child health research across the UK and Ireland (29 October, 2021)
    Katrina Cathie, Alastair G Sutcliffe, Srini Bandi, David Coghlan, Stephen W Turner, Colin Powell

    To improve the management of general paediatric conditions we need better research this paper outlines the unanswered topics most important to parent representatives and paediatricians.

  • Treating nontuberculous mycobacteria in children with cystic fibrosis: a multicentre retrospective study (5 November, 2021)
    Gemma L Saint, Matthew F Thomas, Noreen Zainal Abidin, Ross John Langley, Malcolm Brodlie, Paul McNamara

    Data from 11 cystic fibrosis centres in UK with clinical information on 70 subjects examining nontuberculous mycobacterium (NTM) were collated (60 Mycobacterium abscessus complex (MABSC) 10 M. avium complex (MAC)). Older age and previous diagnosis of allergic bronchopulmonary aspergillosis were all with NTM. There was a wide variance in drug choice and side effects were reported with all agents. NTM eradication occurred in 80% of patients with MAC and 48% with MABSC, with variable outcomes on lung function. Large multi centre studies are required.

  • Non-collagen pathogenic variants resulting in the osteogenesis imperfecta phenotype in children: a single-country observational cohort study (8 November, 2021)
    Patrick Thornley, Nicholas Bishop, Duncan Baker, Joanna Brock, Paul Arundel, Christine Burren, Sarah Smithson, Catherine DeVile, Belinda Crowe, Jeremy Allgrove, Vrinda Saraff, Nick Shaw, Meena Balasubramanian

    Important observational cohort on OI - looking at genetic variants.

  • Paediatric pneumonia: deriving a model to identify severe disease (10 November, 2021)
    Stuart Haggie, Elizabeth H Barnes, Hiran Selvadurai, Hasantha Gunasekera, Dominic A Fitzgerald

    The trajectory after admission in children with community acquired pneumonia is unpredictable. This derivation study based on 3,000 episodes, provides data to guide risk scoring.

Short report

Quality improvement





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