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In April 2020, reports emerged of a new paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS). Numerous clinical uncertainties of PIMS-TS are still contested regularly in clinical practise today. These include distinguishing PIMS-TS from other common causes of childhood febrile illness and its pathogenesis. Disparity in clinical guidance exacerbates this uncertainty. This letter calls for a universal PIMS-TS case definition, which could improve coherency in clinical practise and research.
The first case definition released by the Royal College of Paediatrics and Child Health in May 20201 is broad and takes a cautionary approach to SARS-CoV-2 testing. Case definitions from the WHO2 and the Centers for Disease Control and Prevention (CDC)3 quickly followed with one notable …
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Funding The author has not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.