Table of contents

March 2022 - Volume 107 - 3





Paediatric emergency medicine

  • Improving triage for children with comorbidity using the ED-PEWS: an observational study (21 July, 2021)
    Joany M Zachariasse, Pinky Rose Espina, Dorine M Borensztajn, Daan Nieboer, Ian K Maconochie, Ewout W Steyerberg, Johan van der Lei, Susanne Greber-Platzer, Henriette A Moll

    Through a secondary analysis, the authors assessed the value of the ED-Pediatric Early Warning Score (ED-PEWS) for triage of children with comorbidity. They found that ED-PEWS has a similar performance in children with and without comorbidity and improved triage in most cases.

  • Interventions to reduce acute paediatric hospital admissions: a systematic review (2 August, 2021)
    Smita Dick, Clare MacRae, Claire McFaul, Usman Rasul, Philip Wilson, Stephen W Turner

    Systematic review of interventions and strategies aimed at preventing hospital admission among children and young people finds limited evidence to support their use.

Global child health

  • Neurodevelopment in normocephalic children with and without prenatal Zika virus exposure (3 September, 2021)
    Karen Blackmon, Roberta Evans, Michelle Fernandes, Barbara Landon, Trevor Noel, Calum Macpherson, Nikita Cudjoe, Kemi S Burgen, Bianca Punch, Amy Krystosik, Elysse N Grossi-Soyster, Angelle Desiree LaBeaud, Randall Waechter

    A follow up study of infants born to mothers with pregnancy exposure to Zika virus showed infants who had been exposed to Zika virus but who had a normal head circumference had overall normal development, but all such Zika virus infants should undergo formal visual testing.

  • Lead screening in children presenting to three hospitals in Lebanon (24 August, 2021) Free
    Tharwat El Zahran, Hala Mostafa, Hani Hamade, Moustafa Al Hariri, Aed Saab, Hani Tamim, Rasha Tohme, Dany A Al Hamod, Durriyah Sinno, Rasha Dorothy Sawaya, Ziad Kazzi

    This study in three hospitals in Lebanon studied blood lead levels in 90 children the mean blood lead level was 1.05 μg/dL. All values were below 5.0 μg/dL, a marked decrease compared to before a national ban on leaded gasoline in 2002. The study identified risk factors for higher blood lead levels, including living in a house aged 40 years or more, receiving traditional remedies, and a lower household income.

Original research

  • Mucositis reduction with probiotics in children with cancer: a randomised-controlled feasibility studyEditor's Choice (30 June, 2021) Free
    Hadeel Hassan, Sally Kinsey, Bob Phillips

    This paper describes a feasibility study for an RCT of use of probiotics in reducing mucositis in paediatric cancer patients. It highlights the difficulties inherent in running an RCT of this nature in these patients.

  • Inconsistencies in fertility preservation for young people with cancer in the UK (20 September, 2021)
    Hannah L Newton, Helen M Picton, Amanda Jane Friend, Catherine M Hayden, Mark Brougham, Rachel Cox, Victoria Grandage, Michelle Kwok-Williams, Sheila Lane, Rod Thomas Mitchell, Roderick Skinner, W Hamish Wallace, Daniel Yeomanson, Adam W Glaser

    This study highlights marked variation in provision and funding of fertility preservation services for children with cancer across the UK. Based on these findings, the authors argue that centralised NHS funding should be made available to ensure equitable provision of fertility preservation services and delivery of internationally acknowledged quality standards to all young people with cancer across the UK.

  • Care bundles to reduce unplanned extubation in critically ill children: a systematic review, critical appraisal and meta-analysis (20 July, 2021)
    Paulo Sergio Lucas da Silva, Maria Eunice Reis, Daniela Farah, Teresa Raquel M Andrade, Marcelo Cunio Machado Fonseca

    Review to understand the evidence base for care bundles ie doing multiple improvements at once in children who are intubated to try and prevent unexpected extubation.

  • Infant Escherichia coli urinary tract infection: is it associated with meningitis?
    (20 July, 2021)
    Aisling Rafferty, Richard J Drew, Robert Cunney, Désirée Bennett, John Francis Marriott

    Using a retrospective cohort design, the authors sought to determine the prevalence of co-existing bacterial meningitis in infants and young children in the presence of Escherichia coli urinary tract infection. In 314 patients with UTI and an LP performed, no cases of co-existing E. coli meningitis were identified.

  • Palliative care for children with complex cardiac conditions: survey results (26 July, 2021)
    Sidharth Vemuri, Ashleigh E Butler, Katherine Brown, Jo Wray, Myra Bluebond-Langner

    There is perceived underutilisation of palliative care practitioners in UK paediatric cardiac care. This 2018 UK wide e-survey explores this, confirms it & suggests a more integrated approach with increased training of cardiac practitioners & more embedded palliative care practitioners, before end of life if at all possible.

  • School academic performance of children hospitalised with a chronic condition (2 September, 2021)
    Nan Hu, Joanna Fardell, Claire E Wakefield, Glenn M Marshall, Jane C Bell, Natasha Nassar, Raghu Lingam

    This population-based cohort study using health administrative data examined academic performance in children with chronic conditions who were hospitalised. Compared to children who were not hospitalised, children hospitalized with a chronic condition underperformed in literacy and numeracy domains in grades 3, 5, and 7. A greater number of bed days or hospitalisations was associated with poorer academic performance.





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