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Images in paediatrics
Preterm ovarian hyperstimulation syndrome presenting as clitoromegaly in a premature female infant
  1. Yee Lin Lee1,
  2. Faizah Mohamed Jamli2
  1. 1 Department of Paediatrics, Universiti Putra Malaysia, Serdang, Malaysia
  2. 2 Department of Paediatrics, Hospital Serdang, Kajang, Malaysia
  1. Correspondence to Dr Yee Lin Lee, Department of Paediatrics, Universiti Putra Malaysia, Serdang, 43400, Selangor, Malaysia; yeelin{at}

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A female preterm infant of 25 weeks gestation and birth weight of 760 g was noted to have prominent clitoris at the age of 4 months (postconceptional age 41 weeks). Detailed genital examination revealed oedema of the vulva, pubic area and upper thighs, giving the appearance of clitoromegaly (figure 1A,B). Vaginal and urethral openings were separate. There was no labial fusion and no gonads were palpable. Karyotyping confirmed 46, XX genotype. Normal levels of 17-hydroxyprogesterone, cortisol and testosterone ruled out congenital …

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  • Contributors YLL conceptualised the manuscript and is the main author of this manuscript. FMJ comanaged the patient and reviewed the manuscript critically.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.