Table of contents
November 2022 - Volume 107 - 11
Highlights from this issue
Global child health
- Vitamin D deficiency in South-East Asian children: a systematic review (9 June, 2022)
Vitamin D deficiency remains underdiagnosed worldwide, with significant impacts on many aspects of child health. The high rates of seemingly healthy children in southeast Asia commonly suffering from this condition help bring attention to this hidden form of malnutrition.
- Incidence and aetiology of infant Gram-negative bacteraemia and meningitis: systematic review and meta-analysis (16 June, 2022)
This systematic review confirms the disproportionate burden of Gram negative infections in low and middle income countries, compared to high income countries.
Paediatric emergency medicine
- Rate of invasive bacterial infection in recently vaccinated young infants with fever without source (27 July, 2022)
This secondary analysis of observational registry data compared the rates of IBI (bacterial pathogen in blood or cerebrospinal fluid) and urinary tract infection (UTI) in febrile infants between 42 and 90 days of age who had and had not been vaccinated in the previous 48 hours and conclude that UTI screening remains appropriate, but with further study the need for IBI screening in recently vaccinated infants could be revisited.
- Paediatric health-related quality of life in congenital cytomegalovirus (29 June, 2022)
What is the Health Related Quality of life (HRQoL) for children with congenital CMV (cCMV) infection and their parents?This study found cCMV has a significant effect on the HRQoL of children with cCMV and their parents, with the children with the most significant health needs having the lowest HRQoL compared to those children with little or no effects on their health.This information could help assess the possible benefits of screening for cCMV.
- Trajectories of transgender adolescents referred for endocrine intervention in England (28 July, 2022)
This paper presents the endocrine treatment trajectories of a cohort of gender-diverse adolescents attending the largest child gender service in Europe.
- Discharge outcome analysis of 1089 transgender young people referred to paediatric endocrine clinics in England 2008–2021 (18 July, 2022)
This paper reports post-discharge outcomes of a large national cohort of transgender and gender variant young people who were referred by the NHS Gender Identity Development Service (GIDS) to, and discharged from, the two English NHS paediatric endocrine liaison centres clinics.
- Diabetic ketoacidosis fluid management in children: systematic review and meta-analyses (23 June, 2022)
This review and metanalysis of fluid management in paediatric diabetic ketoacidosis found no evidence that the rate of fluid administration has any effect on clinical outcomes or length of stay.
- PEPtalk 3: oral aciclovir is equivalent to varicella zoster immunoglobulin as postexposure prophylaxis against chickenpox in children with cancer – results of a multicentre UK evaluation (8 July, 2022)
This UK based multi-centre service evaluation compared oral aciclovir with varicella immunoglobulin in children with cancer. It demonstrated non-inferiority in terms of safety and efficacy. Thus adding to the body of evidence confirming that aciclovir can be considered as standard of care in this patient group.
- Early weight gain influences duration of breast feeding: prospective cohort study (15 July, 2022)
In this longitudinal cohort study of term, singleton, normal birthweight, initially exclusively breastfed infants, slower weight gain while exclusively breast feeding was associated with higher likelihood of introduction of infant milk formula in subsequent follow-up periods, between 2 and 11 weeks.
- Families’ experiences of central-line infection in children: a qualitative study (21 July, 2022)
In this qualitative study using semi-structured interviews of caregivers of children with central-venous access devices, families report that living with the risk of central line-associated bloodstream infections poses important burdens on families that impact their physical and emotional well-being.
- Evolution of paediatric eating disorders in Singapore: a historical cohort study (18 July, 2022)
An epidemiological study depicting the evolution of paediatric eating disorders over the last 30 years in Singapore and the region.
- Oral saliva swab reverse transcription PCR for Covid-19 in the paediatric population (10 June, 2022)
The results from this multi-centre prospective diagnostic test accuracy study suggest that molecular testing of oral saliva samples for SARS-CoV-2 in children is an accurate and less invasive alternative to molecular testing of nasopharyngeal/oropharyngeal swabs.