Table of contents

October 2022 - Volume 107 - 10

Highlights from this issue

  • Atoms (20 September, 2022) Free
    Nick Brown




Global child health


Paediatric emergency medicine

  • Outpatient parenteral antimicrobial therapy: how young is too young? (10 May, 2022)
    Kate Alison Hodgson, Ruth Lim, Julie Huynh, Ben Nind, Naomi Katz, Robin Marlow, Conor C Hensey, Barry Scanlan, Laila F Ibrahim, Penelope A Bryant

    A prospective 8-year observational study from September 2012 to September 2020 including 76 episodes for which neonates were admitted to the Hospital-in-the-Home (HITH) for outpatient parenteral antimicrobial therapy (OPAT), and 405 episodes for older infants evaluated the use, the efficacy and the outcomes of OPAT in neonates (≤28 days of age), compared with older infants (1-12 months of age). This study demonstrates that OPAT is a safe and effective way of providing antibiotics to selected clinically stable neonatal patients. Whilst appropriate antibiotic use was common, improvements can still be made.

  • Local nitroglycerin to facilitate peripheral arterial cannulation in children: systematic review and meta-analysis (20 May, 2022)
    Deepika Wagh, Dinesh Pawale, Jason Khay Ghim Tan, Shripada C Rao

    Topical nitroglycerin may hep arterial cannulation.

Original research

  • Trends in weight loss attempts among children in England (18 July, 2022)
    Aryati Ahmad, Melissa Little, Carmen Piernas, Susan Jebb

    Paper describe trends in reported weight loss attempts among school-aged children. 34,235 children were analysed. Weight loss attempts among children is increasing at a faster rate than the rise in excess weight and includes an increasing proportion of children with a ‘healthy’ weight.

  • Do you know when the inhaler is empty? (12 May, 2022)
    I Fullwood, T Evans, Benjamin Davies, T Ninan, C Onyon, J Clarke, Rajesh Srikanthiah, Susan Frost, N Iqbal, M Atkinson, Satish Rao, Prasad Nagakumar

    Patients cannot reliably identify when their child’s inhaler is empty. There is an urgent need for improving inhaler technology and providing appropriate guidance on how to identify when an MDI inhaler is empty.

  • Feasibility of single question mental health surveillance in chronic disease (9 June, 2022)
    Mary White, Rachel Pelly, Jane Le, Lucy Dove, Sarah Connolly, Alice Morgan, Dave Reid, Ric Haslam, Harriet Hiscock

    The introduction of a single mental health screening question to a paediatric chronic illness clinic was feasible and acceptable to staff and families. It was a useful tool to identify those requiring more in depth assessment.

  • Oral and Swallowing Abilities Tool (OrSAT) in nusinersen treated patients (16 May, 2022)
    Beatrice Berti, Lavinia Fanelli, Giulia Stanca, Roberta Onesimo, Concetta Palermo, Daniela Leone, Roberto de Sanctis, Sara Carnicella, Giulia Norcia, Nicola Forcina, Giorgia Coratti, Maria Carmela Pera, Valentina Giorgio, Carolina Ausili Cefaro, Richard Finkel, Marika Pane, Eugenio Mercuri

    New interventions have radically altered the natural history of Spinal Muscular Atrophy. In this report, oral and swallowing outcomes are report following interventions, widening our understanding of the potential benefits of early treatment.

  • Maternal mental health and substance use disorders in sudden unexpected death in infancy using routinely collected health data in New Zealand, 2000–2016 (8 June, 2022)
    Edwin A Mitchell, Doney Zhang, John M D Thompson, Chris Liu, Alison Leversha, Barry J Milne

    This population-based cohort study of live births in New Zealand using health administrative data showed maternal substance use disorders but not maternal mental health problems in the year prior to an infants birth was associate with a moderately increased risk of sudden unexplained death of infancy.

  • Postoperative morbidities with infant cardiac surgery and toddlers’ neurodevelopment (6 July, 2022)
    Julie Read, Deborah Ridout, Samantha Johnson, Aparna Hoskote, Karen Sheehan, Paul Wellman, Alison Jones, Jo Wray, Katherine Brown

    A multi-centre followup study evaluating neurodevelopmental outcomes of children aged 2-3 years who underwent infant cardiac surgery and experienced post-operative morbidities compared to matched controls who did not have complications.

  • Adherence to the 2015 and 2020 British Society of Paediatric Endocrinology and Diabetes guidelines and outcomes in critically ill children with diabetic ketoacidosis: a retrospective cohort study (16 June, 2022)
    Victoria Mary Edwards, Claire Procter, Andrew J Jones, Elise Randle, Padmanabhan Ramnarayan

    UK retrospective cohorts fails to show differences in outcomes with 2015- vs 2020-BSPED fluid protocols for DKA management.

  • Short-course intravenous antibiotics for young infants with urinary tract infection (25 April, 2022)
    Jolie Lawrence, Laure F Pittet, Samar Hikmat, Eloise J Silvester, Vanessa Clifford, Rodney Hunt, Amanda Gwee

    This study aimed to determine the safety of early IV-to-oral antibiotic switch, and identify risk factors for bacteraemia with UTIs. Short course IV antibiotics for <48 hours for young infants with non-bacteraemic UTI should be considered, provided meningitis has been excluded. Treatment failure and serious complications were rare in young infants with UTI.

  • Factors that may improve paediatric workplace-based assessments: an exploratory study (29 June, 2022)
    Kimberley Jefferies

    By using semi-structured interviews, this study looks at trainees’ and assessors’ views of workplace-based assessments, identifying time, training and limitations of technology as barriers to completion.

Drug therapy


Electronic pages