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917 A DGH experience of cooling in hypoxic ischemic encephalopathy
  1. Niamh Scally,
  2. Arunava Kundu
  1. St Helier Hospital


Background Hypoxic ischaemic encephalopathy (HIE) is a serious complication arising from impaired cerebral oxygenation in the perinatal period, which confers a high rate of mortality, morbidity and developmental delay. The Total Body Cooling (TOBY) Trial showed that moderate-induced hypothermia improves survival and neurological outcomes, and provides national criteria for patient cooling. We have been managing babies with therapeutic hypothermia in our unit since 2009. Here we report our single-centre District General Hospital experience of managing HIE over an 8-year period with two year follow up data.

Objectives To examine the 2 year developmental outcomes for our cohort of patients with HIE, since cooling was introduced at our centre in 2009.

Methods A retrospective review of patients with a coded diagnosis of HIE managed at St. Helier Hospital was performed via electronic healthcare records. All patients treated between 1/10/2009 and 1/10/2017 were included for analysis. Non electronic records were then used to obtain detailed information about each patient at the time of HIE diagnosis and follow up at 2 years of age.

Results After manual exclusion of non-HIE cases (n=12), 55 patients with a coded diagnosis of HIE were identified and included in the analysis. The mean gestational age was 39.3 weeks (range 32–42), and most were born at our centre (76%). At the time of review, 47 (85%) were alive and 8 (16%) had died. 28 patients (51%) received cooling, 25 of which were cooled at our centre. In this latter group, 24 (96%) met both TOBY criteria A and B. The mean pH of cooled babies was 7.001 (range 6.53–7.38), and the median Apgar Score at 1 minute was 2 (range 0–9), at 5 minutes was 4 (range 0–10) and 10 minute was 6 (range 0–10). Of the 18 patients who were cooled in our trust with local follow-up data available, 8 (44%) had normal motor, speech and language development at 2 years, and 10 (55%) had abnormal development in one or both domains which reflects the original TOBY data (where survival without a neurologic abnormality was 44% at 18 months in the cooled group). Of patients who did not meet criteria, were not cooled and had local follow up (n=19), 6 (31%) had abnormal developmental outcomes at 2 years with 3 (15.7%) of children demonstrating both motor and speech delay.

Conclusions Looking back at our decade of experience since the introduction of cooling, our analysis shows that the outcomes from the original TOBY trial translate well to a DGH setting. Although we were compliant with TOBY criteria and had similar outcomes for our cooled babies, we found that over 8 years, 33% of patients who were appropriately not cooled had abnormal developmental outcomes at 2 years. Is there a case for cooling babies below the threshold set by the TOBY trial?

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