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  • Two-year outcomes of therapeutic hypothermia in perinatal hypoxic–ischaemic encephalopathy cases at Chiang Mai University Hospital

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Two-year outcomes of therapeutic hypothermia in perinatal hypoxic–ischaemic encephalopathy cases at Chiang Mai University Hospital
  1. Varangthip Khuwuthyakorn,
  2. Shanika Kosarat,
  3. Watcharee Tantiprabha,
  4. Somporn Chotinaruemol,
  5. Kamornwan Katanyuwong,
  6. Orawan Louthrenoo,
  7. NICU working group
  1. Department of Paediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
  1. Correspondence to Dr Varangthip Khuwuthyakorn, Department of Paediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand; vkasiwat109{at}gmail.com

https://doi.org/10.1136/archdischild-2020-318880

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    This study aimed to report long-term outcomes of 23 infants with perinatal hypoxic–ischaemic encephalopathy (HIE) who underwent therapeutic hypothermia (TH) at Chiang Mai University Hospital between February 2013 and February 2015. Informed consents were obtained at the follow-up clinic. The Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) was employed by developmental–behavioural paediatricians; visual impairment was evaluated by ophthalmologists and otoacoustic emissions (OAE)/auditory brainstem response (ABR) was used to identify any hearing impairment. Severe disability was defined by any of the following: Bayley-III (any domains)<70, Gross Motor Function Classification System≥3, severe visual impairment and profound hearing impairment. The results demonstrated that death, severe disabilities, and combined death and severe disabilities were 36.4%, 23.5% and 58.8%, respectively (table 1 and figure 1). If the analysis included lost to follow-up and non-participating patients, those outcomes would …

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    Footnotes

    • Collaborators NICU working group: Navapun Papana, Sariya Thongsawang, Chaweewan Prasertwitayakij and Nuananong Crutpant.

    • Contributors VK: wrote the proposal, enrolled participants, provided physical examination, collected data, wrote the manuscript, and edited the final draft of manuscript. SK: edited the proposal and the manuscript, and read the final draft of the manuscript. WT: edited the proposal and the manuscript, supervised overall work, and read the final draft of manuscript. SC: edited the proposal and the manuscript, and read the final draft of the manuscript. KK: provided neurological assessment, edited the proposal and the manuscript, and read the final draft of the manuscript. OL: provided developmental assessment, edited the proposal and the manuscript, and read the final draft of the manuscript. NICU working group: NICU data collection.

    • Funding This study was supported by the Faculty of Medicine, Chiang Mai University (grant number 046/2559).

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.