Article Text

Download PDFPDF
Longitudinal outcomes of well, term infants who present with persistent hyperthyrotropinaemia
  1. Sze May Ng1,2,
  2. Nancy Katkat1,
  3. Tal Oryan1,
  4. Omokayode M Ayoade1,
  5. Mahreen Aleem1
  1. 1 Paediatric Department, Southport and Ormskirk NHS Trust, Ormskirk, UK
  2. 2 Department of Women’s and Children’s Health, University of Liverpool, Liverpool, UK
  1. Correspondence to Dr Sze May Ng, Paediatric Department, Southport and Ormskirk NHS Trust, Ormskirk L39 2AZ, UK;{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

In congenital hypothyroidism, early treatment with thyroid replacement reduces severe developmental deficits.1 Hyperthyrotropinaemia is defined as elevated thyroid-stimulating hormone (TSH) with normal free-thyroxine (FT4) levels. The clinical significance of HT remains unclear. Proposed aetiologies include immaturity of the hypothalamic–pituitary–thyroid axis, presence of thyroid antibodies and thyroid genetic defects.2 There is no consensus on management, and the decision to treat lies solely on the clinician’s decision. The aim of this study was to review the course of persistent hyperthyrotropinaemia in well, term infants and to determine the risk of decompensation in this cohort of infants.

Between 2012 and 2108, 2115 term infants who had thyroid function tests (TFTs) undertaken as part of a prolonged jaundice screen were reviewed. Screening for congenital hypothyroidism was done with blood spot …

View Full Text


  • Twitter @mayng888

  • Contributors The concept was developed by SMN. All authors analysed, drafted and approved the final paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.