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Hypertonic saline in bronchiolitis: an updated meta-analysis
  1. Paula Heikkilä,
  2. Matti Korppi
  1. Tampre Center for Child Health Research, Tampere University, Tampere, Pirkanmaa, Finland
  1. Correspondence to Dr Matti Korppi, Tampere Center for Child Health Research, Tampere University, Tampere 33014, Finland; matti.korppi{at}

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Hypertonic saline (HS) inhalations in infants hospitalised for bronchiolitis are still under discussion, although 20 randomised controlled trials (RCTs) have evaluated the effectiveness.1–3 Two RCTs, one from Japan2 and another from Switzerland,3 were published until 31 January 2020 after our cumulative meta-analysis,1 which covered data until 30 June 2017.

Morikawa et al randomised 63 Japanese children hospitalised for moderately severe bronchiolitis caused by respiratory syncytial virus at <12 months of age to receive 3% HS and 65 to receive normal saline (NS) inhalations four times a day.2 Saline inhalations were routinely administered combined with nebulised salbutamol. Nine (14.3%) and 7 (10.9%) children, respectively, received additional inhalations. Jaquet-Pilloud et al …

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  • Contributors PH performed the analyses, and PH and MK wrote together the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.