The Archivist has seen the impact of Sepsis six and now, Sepsis three with concern about the over use of antibiotics and antimicrobial resistance. Rudd KE et al (Lancet 2020;395(10219):200–211 https://doi.org/10.1016/S0140-6736(19)32989-7] gives us an important reminder about the worldwide seriousness and impact of this devastating disease. The Global Burden of Disease (GBD) is a group of more than 3600 researchers examining health issues from around the world. GBD 2017 reports on 282 underlying causes of death in 195 countries. This group has estimated the global, regional, and national incidence …