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Response to: Management of fluids in paediatric diabetic ketoacidosis: concerns over new guidance
  1. Neil Wright1,
  2. Rum Thomas2
  1. 1 Paediatric Endocrinology and Diabetes, Sheffield Children's Hospital, Sheffield, UK
  2. 2 Paediatric Intensive Care Unit, Sheffield Children's Hospital, Sheffield, UK
  1. Correspondence to Dr Neil Wright, Paediatric Endocrinology & Diabetes, Sheffield Children's Hospital, Sheffield S10 2TH, UK; n.p.wright{at}

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Despite the introduction of more restrictive fluid in the management of diabetic ketoacidosis (DKA) such as that advocated by Lillie et al,1 there is little epidemiological evidence to suggest that more restrictive regimens have reduced the incidence of cerebral oedema. Cerebral oedema occurs prior to the administration of fluid in up to 19% of cases, and subclinical oedema has been demonstrated on MRI in up to 50% of cases.2 3 Why some patients evolve cerebral oedema and others do not and the role of fluids remain unclear and contentious. Experts suggest that it results from initial hypoperfusion followed by vasogenic/reperfusion injury rather than the traditional view of osmotic changes.

In 2019, a multidisciplinary expert working group (including paediatric intensivists) was convened by the British Society of Paediatric Endocrinology and Diabetes to review the previous guideline published in 2015 …

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  • Twitter @rum_thomas11

  • Contributors NW and RT co-chaired the British Society of Paediatric Endocrinology and Diabetes Diabetic Ketoacidosis Working group reviewing and revising the diabetic ketoacidosis guideline. Both contributed to drafting this response.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Commissioned; internally peer reviewed.

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