Translating the Nurturing Care Framework and unprecedented global policy support for early child development (ECD) into action requires evidence-informed guidance about how to implement ECD programmes at national and regional scale. We completed a literature review and participatory mixed-method evaluation of projects in Saving Brains®, Grand Challenges Canada® funded ECD portfolio across 23 low- and middle-income countries (LMIC). Using an adapted programme cycle, findings from evaluation related to partnerships and leadership, situational analyses, and design for scaling ECD were considered. 39 projects (5 ‘Transition to Scale’ and 34 ‘Seed’) were evaluated. 63% were delivered through health and 84% focused on Responsive Caregiving and Early Learning (RCEL). Multilevel partnerships, leadership and targeted situational analysis were crucial to design and adaptation. A theory of change approach to consider pathways to impact was useful for design, but practical situational analysis tools and local data to guide these processes were lacking. Several RCEL programmes, implemented within government services, had positive impacts on ECD outcomes and created more enabling caregiving environments. Engagement of informal and private sectors provided an alternative approach for reaching children where government services were sparse. Cost-effectiveness was infrequently measured. At small-scale RCEL interventions can be successfully adapted and implemented across diverse settings through processes which are responsive to situational analysis within a partnership model. Accelerating progress will require longitudinal evaluation of ECD interventions at much larger scale, including programmes targeting children with disabilities and humanitarian settings with further exploration of cost-effectiveness, critical content and human resources.
- early child development
- child health
- health policy
- health systems
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WHY? Time to accelerate implementation for early child development (ECD): translating unprecedented global policy support, including the Nurturing Care Framework, into action requires evidence-informed guidance about how to implement ECD programmes at national and regional scale.
WHAT IS NEW? Contextual design choices: targeted situational analyses are crucial for adaptation and should be guided by pathways to impact (eg, theory of change) and local formative data wherever possible.
WHAT TO DO? Partnerships and leaderships: key and emerging networks focusing on action at national level provide a resource for those with responsibilities for programme development and implementation.
KEY GAPS? Implementation and research gaps to close: accelerating progress requires more structured tools for situation analyses and design decisions including how to integrate care of children with disabilities and in humanitarian settings. Implementation research to understand impact at much larger scale, over longer time frames and including cost-effectiveness data needs to be embedded.
What is needed to support scaling of early child development?
The Sustainable Development Goals and Global Strategy for Women’s, Children’s and Adolescents’ Health (2016–2030) aim to ensure that every child has the opportunity to thrive, or reach their best developmental potential.1 2 The WHO, UNICEF and World Bank ‘Nurturing care for early childhood development: a framework for helping children survive and thrive to transform health and human potential’ (Nurturing Care Framework, NCF) provides a policy framework to support these ambitions (figure 1).3 As well as increased global focus on early child development (ECD), there has been a steady increase in ECD policy uptake with 45% of low- and middle-income countries (LMIC) having national, multisectoral ECD policies.4
However, few LMIC have implemented large-scale ECD programmes, and there are no consistent measures of coverage and quality.5 Hence, to operationalise the NCF, there is increased demand for evidence to inform design, implementation and measurement of ECD programmes at scale.4 6–8
Saving Brains, Grand Challenges Canada (GCC) represents the largest innovation investment in ECD projects in LMIC so far and is a unique opportunity to explore decision processes related to programme design, implementation and scaling in diverse settings.9 Saving Brains was designed to support healthy brain development for children in the first 1000 days through innovations that prevent brain injury, promote stimulating and responsive environments and protect children from developmental risk factors.9 Between 2011 and 2016, Saving Brains invested Can$43 million in 108 grants to teams based in LMIC.9 Most projects were ‘Seed’ (proof of concept) with 18–24 months’ duration and a minority were ‘Transition to Scale’ (TTS) grants with 2–3 years’ duration and the aim to scale up. All are led by LMIC organisations and are supported by a multi-institutional platform that provides technical and practical support.10 Saving Brains uses a portfolio-level theory of change to consider pathways to impact (supplementary web appendix figure A).9 Our evaluation relates to all Saving Brains Seed and TTS projects completed by February 2017 (supplementary web appendices textbox A, tables A and B).
Supplementary file 1
Purpose, scope and structure of series
The purpose of this series is to inform decisions related to design and implementation of ECD interventions at national and subnational levels in diverse LMIC. ECD occurs within a life-cycle continuum, but here we focus especially on pregnancy to 3 years. We have adapted a generic programme design and implementation cycle to apply to ECD (figure 2A) and consider key processes and decision points within that (figure 2B).
Each paper relates to a specific aspect of the programme cycle. This first paper focuses on the centrality of partnerships, leadership, situational analysis and the major decisions in ECD programme design (eg, sectoral entry point, targeted vs universal approaches). Subsequent papers consider monitoring and evaluation,11 12 financing,13 and overall process to scale up.14
The first two papers, including this paper, draw directly on mixed-method evaluation of the Saving Brains portfolio, with case studies from the TTS Saving Brains grants, while other papers build on additional analyses.
Objectives of this paper
Describe processes and decision points in an ECD programme cycle for scale-up.
Synthesise findings of Saving Brains evaluation related to the ECD programme cycle, specifically: partnership and leadership, situational assessment, adaptation to context and programme design choices.
Objective 1. Describe processes and decision points in an ECD programme cycle for scale-up
Based on literature in other areas of global child health and ECD as well as findings of Saving Brains portfolio evaluation, we adapted a generic programme cycle and systematically considered key decision points in the process of ECD programme design, implementation and scale-up.15–17
Objective 2. Synthesise findings from the Saving Brains portfolio evaluation related to processes and decision points in ECD programming
We completed an impact and process evaluation of projects funded by Saving Brains, GCC, between 2011 and 2016. Evaluation was led by a team from the London School of Hygiene & Tropical Medicine in collaboration with the Saving Brains partnership, True Point/Harvard University and the WHO. We used a participatory mixed quantitative and qualitative approach to evaluate the portfolio as whole (box 1). Qualitative themes explored were arranged around key decision points in the programme cycle (figure 2A).
Cameroon and Mali case study: scaling up Kangaroo Mother Care (KMC) to help newborns survive and thrive
An established evidence base from high-resource settings demonstrates that developmental care initiated soon after birth can have positive effects on early developmental outcomes among high-risk infants.31 KMC for low birthweight (LBW) and preterm newborns is an example of an early nurturing care intervention that has the potential to improve survival and to positively impact on short-term and long-term neurodevelopmental outcomes.
Among the Saving Brains portfolio, one Transition to Scale (TTS) project looked specifically at implementation of KMC for small and preterm newborns in a multicountry low-resource sub-Saharan African setting. This built on previous work showing short-term and mid-term benefits on survival, neurodevelopment and mother–infant bonding,32 and also a 20-year KMC follow-up cohort that showed significant long-lasting protective social and behavioural effects extending into adolescence and young adulthood.33
The TTS project focused on scaled implementation of KMC in Mali and Cameroon, including two ‘centres of excellence’ and 10 regional health facilities. The intervention package consisted of promotion and support of breastfeeding and skin-to-skin contact after birth for stable LBW newborns, and included home visits up to 28 days of age. The project team examined effect on survival, anthropometric outcomes including head growth, exclusive breastfeeding rates, rates of KMC and KMC education. Early child development outcomes were not directly measured.
A key aspect of programmatic learning regarding implementation was the importance of in-country leadership and ‘buy in’ at all levels, but particularly at individual facility level. Lack of infrastructure, in way of equipment and materials, was highlighted as a key challenge in delivering KMC. Introduction of an E-learning platform to facilitate quality practice was particularly well received, with teams reporting high levels of self-directed knowledge transfer and positive experiences of high-quality training in an easy-to-navigate format.
Interventions typically thought of as targeting newborn and child survival also have the potential to promote early child development. Local buy-in from in-country leaders and establishment of local protocols and infrastructure can be crucial to the success of these programmes. E-learning platforms may be a useful adjunct for high quality and coverage of training when implementing at scale.
Objective 1. Processes and decisions in an ECD programme cycle for scale-up
Figure 2A,B describes the processes and decision points in programme design, implementation and scale-up according to previously described methods.
Objective 2. Findings from the Saving Brains portfolio evaluation related to ECD programming
Thirty-nine projects were implemented across 23 LMIC between September 2013 and November 2016 including 34 Seed and five larger TTS projects, some of which were being scaled up from previous Seed projects (table 1 and supplementary web appendix table C). Projects were diverse in terms of context, design, content, implementation strategy and size (n=41–2500 participants). A summary of Seed grants is provided in supplementary web appendix table C. Programme decisions for TTS grants which focused on RCEL are summarised in table 1 with further details of individual programme case studies summarised in boxes 1–4.
Bangladesh case study: designing an integrated early child development (ECD) intervention for undernourished children for scale-up through government health services
In Bangladesh, a diverse and densely populated country, national-level indicators reflect substantial progress in child health over several decades with impressive reductions in overall under-5 mortality, although substantial inequities remain.24 There is also high-level governmental recognition of the importance of early child development which has been incorporated into a national plan of action.37
Local researchers reviewed integration of responsive caregiving ECD interventions into health and nutrition services in Bangladesh.37 Findings suggested that existing ECD programmes through government services were either limited in scope or had not been adequately evaluated.37 Conversely, a number of high-quality local intervention trials had previously demonstrated feasibility and effectiveness of responsive caregiving interventions when implemented at small scale.38–44 Specifically, previous trials in Bangladesh had demonstrated positive impact of responsive caregiving interventions on early child development outcomes for undernourished children and when integrated with interventions for mothers with depression at small scale.38–44
To build on this existing local evidence, scale-up and evaluation of interventions implemented in routine services, a team from the International Centre for Diarrhoeal Disease Research Bangladesh (ICDDR,B) funded by Saving Brains completed a cluster randomised trial to assess impact of a responsive caregiving intervention integrated into routine primary health services.
Researchers built on long-standing relationships with local partners and particularly targeted the government health sector for partnership in scaling in order to support sustainability and to use existing infrastructure, particularly 13 000 primary healthcare clinics nationally.
Challenges, both anticipated and unexpected, were experienced but not insurmountable. Poor initial attendance at sessions was managed through greater engagement of families and communities in intervention adaptation and implementation design processes. Various incentivisation strategies were considered and tried, however, being mindful of logistics with scaling, strategies that focused on communication, engagement and awareness raising rather than material incentivisation were selected. Changes in government nutrition programmes during the course of implementation which were outside the researchers’ control, meant that provision of nutritional supplements was not possible, and therefore the nutritional intervention component focused on counselling only. There were also anticipated challenges with government staff workload, motivation and expectation of remuneration. Engagement of front-line workers as well as existing supervisors in the process of implementation was important in overcoming these challenges.
In spite of these challenges, the responsive caregiving intervention was successfully implemented in 90 clinics with evaluation findings in process.18
Moving forward, researchers plan to continue with intervention scale-up through government services, noting that their role is likely to change with scaling. Specifically, in the next phase of scaling, transitioning responsibility for staff supervision and training to government workers will be evaluated.18 To reach children at geographic distance, engagement of other partners and new delivery strategies are also being considered (eg, non-governmental organisation (NGO) sector, media).
Brazil case study: designing an adapted Responsive Caregiving and Early Learning (RCEL) programme for children in urban slums
Brazil has made remarkable progress for child nutrition and survival over the past decade, with particularly impressive results in large urban areas. In Sao Paulo, infant mortality has now dropped to 11 deaths per 1000 and prevalence of stunting to less than 10%. However, large socioeconomic disparities remain, especially in urban areas where lower socioeconomic status (SES) families often live in illegal slum settlements characterised by poor hygiene, high levels of environmental pollution and violence. Children growing up in these poor urban settlements are exposed to a high burden of adverse environmental exposures and often lack support of traditional social and family structures in rural communities. Additionally, there is lack of institutional child care for the urban poor: while early childhood care centres (crèches) are commonly used among middle and upper class parents, less than 10% of the poor urban population targeted by this project benefit from such services.45 As in most low- and middle-income countries, Brazil’s child policy efforts have historically been focused on child health and formal schooling, which starts at age 6.
Universal or targeted?
A large literature suggests that developmental differences emerge in the first 1000 days; even though catch-up at later ages is possible to some extent, early programmes like the ones evaluated here may be the most effective tool to reduce socioeconomic and intergenerational disparities, and thus complement current social protection policies. Over recent years, interest in early childhood care has been increasing in Brazil. However, there has been a gap in public early child development programming for children below school age.46 However, the policy environment for development of such services was favourable with a plan to provide mandatory enrolment in kindergarten for all children starting from age 4 by 2015 (bill passed in April 2013). Therefore, researchers from the University of Sao Paulo opted for a targeted approach, focusing their intervention towards children below school age and low SES families from the urban settlements in the western region of Sao Paulo.
Existing, free government health services (SUS) are primarily used by low SES groups with a reach, according to latest estimates of 55.6% of urban households in Sao Paulo. Therefore, researchers considered government family health services as a potential platform for implementation of a home visiting programme as a first step towards larger regional or national programmes. Home visiting programmes have been proven effective in improving early child development and maternal well-being in a number of countries, and given Brazil’s proven capacity in implementing large-scale social protection and health programmes, this was considered a potentially feasible platform for scaling. Although evidence based, since there were a number of questions regarding implementation of parenting programmes in this context, researchers developed a pilot project which aimed to assess the feasibility, potential impact and cost-effectiveness of established home visiting programmes in the local context.
Smith et al recently reported on evaluation of intervention adaptation and implementation in Brazil.35 During implementation, multiple adaptations were made to the base programme including adaptations of content, delivery strategy (eg, frequency of home visit), personnel and materials. The adapted programme was implemented by both existing government health workers as well as a new cadre of worker or ‘community developmental assistants’. Overall, the adapted parenting programme was well accepted by caregivers and front-line workers. Use of a clear structured curriculum, training and supervision approach was considered an important enabling factor. However, challenges were experienced with high turnover and low prioritisation of the intervention by salaried government workovers in the context of their broader workload.
Careful consideration of human resource requirements including cadre of worker, case load, scheduling, training and supervision is a key consideration to support feasibility of implementation with further scaling.
Colombia case study: designing an enhanced Responsive Caregiving and Early Learning (RCEL) programme through government services
Multiple stakeholders emphasised the policy and programming relevance of cost-effectiveness of interventions. Specifically, innovating teams reported strong demand for data on cost and cost-effectiveness, relevant to the local setting. However, across the portfolio, 45% of teams reported direct costs and very few reported indirect costs. Within the constraints of Seed grants, teams reported that demonstration of cost-effectiveness was their key priority but they lacked technical expertise and other resources to effectively measure this from an early stage. However, among larger Transition to Scale (TTS) grants, an intervention in Colombia to improve the quality of a pre-existing parenting programme was demonstrated to be effective and relatively affordable compared with the cost of various alternatives with lower impacts.
In Colombia, a partnership led by the Universidad de Los Andes sought to improve an existing parenting programme to deliver an integrated responsive caregiving and nutrition intervention to children in a socioeconomically deprived population subgroup. The enhanced parenting programme included incorporation of an early stimulation curriculum inspired by the Reach Up curriculum, nutritional supplementation, and programme provider training and supervision protocols, and was delivered through group meetings. It was evaluated through a cluster (town) randomised controlled trial delivered across 87 towns in three departments in central Colombia for an average of 10.4 months. In control towns, children received the unenhanced government parenting programme (Family, Women and Infancy Program, FAMI).
At follow-up, positive effects were noted on child development including improved cognition (~+0.15 SD), receptive language (0.11 SD), expressive language (0.14 SD) and gross motor scores (0.14 SD) compared with active controls using Bayley-III. Reductions in stunting (0.13 SD) and improvement in parental practices and caregiving environment were also noted.35 These effects were noted even though exposure in the intervention group was lower than intended.
In addition to measuring impact, cost of the enhanced parenting programme compared with local programming alternatives was also evaluated. The cost of the unenhanced government parenting programme was estimated to be US$310 per child/year while cost of enhancement was US$320 per child/year. Additional costs included both the pedagogical (US$122/year) and nutritional (US$212/year) components. These costs compare favourably to estimated costs of centre-based care for children aged 6 months to 5 years which are estimated to be US$1100. Furthermore, the estimated effect of centre-based care compared with home-based care is, on average, only about 0.05 SD.17
In this middle-income setting the enhancements to existing community-based, parenting programmes compare favourably to centre-based options at a fourth of the cost.
Partnerships and leadership
Multilevel partnerships for scaling
Qualitative data reflected the importance of partnerships to intervention design and implementation. In Seed projects, implementing teams valued technical expertise in ECD, research, monitoring and evaluation. By contrast, TTS teams already had considerable ECD expertise and were led by local groups with established track records. These partnerships, focused towards scaling, were multilevel and typically built on long-standing relationships with community, government, non-governmental organisation (NGO) and academic institutions (table 1).
Leadership at multiple levels
The importance of leadership both at higher political and lower system levels was emphasised. For example, in Bangladesh, the support of government health workers in motivating workers at clinic level, and facility-level support to mobilise practical resources for implementation at local level during Kangaroo Mother Care (KMC) scale-up in Mali and Cameroon, was crucial.
Roles of different sectors
Government partnerships, predominantly health, were key for scaling and sustainability in TTS projects. In Bangladesh, Brazil and Colombia, the focus was on implementation of RCEL programmes through health and social protection services. This required adaptation of interventions to account for case load, incentivisation, intervention strategy and dosage, and meant that projects were more vulnerable to political instability and loss of direct control of implementation. However, these challenges were balanced against reach and perceived sustainability of government services. Furthermore, in spite of challenges, published findings demonstrate the feasibility and effectiveness of integrating interventions into existing government services (boxes 1–4).16–18
In the Mobile Crèches project in India, the private sectors (NGOs and construction companies) were chosen as primary implementation partners to reach children not already connected with government health services. Qualitative feedback also highlighted the potential role of the private sector for other reasons (eg, for experience in scaling models). Sectoral partnerships with child protection and disability were not well explored across the portfolio although are the focus of ongoing Saving Brains projects.19
Families and communities as partners in design and implementation
Active partnership with families and communities was important and was achieved through various methods (ie, inclusion in situational analysis and piloting, participation of family members as front-line workers and through consideration of family perspectives in monitoring and evaluation). One project (Vietnam) specifically focused on father engagement.
Situational analysis and adaptation to context
Projects were based in Africa, Eastern Europe, the Middle East, Central America and South-East Asia. Seven (30%), 11 (48%) and 5 (22%) projects were implemented in low, low-middle and upper middle-income countries, respectively (according to World Bank definitions).20 Upper middle-income projects were implemented mostly in Brazil (Since Saving Brains has a partner organisation, Fundação Maria Cecilia Souto Vidigal (FMCSV) in Brazil). Child health, education and equity profiles of project sites varied. Only one project (Democratic Republic of Congo) was implemented in a humanitarian setting (table 1, supplementary web appendix table C).
Detailed understanding of context through formative research and piloting was considered crucial to implementation design and effectiveness. TTS teams using the ‘Reach Up’ curriculum made adaptations to content, delivery strategy, target population, materials, personnel, training, supervision and sociocultural context to suit their contexts in Bangladesh, Colombia and Brazil (table 1). These adaptations were important to ensure feasibility, acceptability and potential sustainability and scalability of interventions across settings. Context-specific adaptation of parenting programmes in Bangladesh is outlined in box 3 to highlight the importance of ongoing adaptation during implementation and scaling.
In spite of the importance given to situational assessment and contextual adaptation, these factors were typically based on implicit local knowledge in the absence of structured tools to support situational assessment and given an absence of population-level data on ECD.
The importance of understanding financial context was also highlighted repeatedly, however it was difficult for projects to track cost data. One project (Colombia) explored cost in detail (box 4).
Sectoral entry point
Most project teams (63%) used health as the primary entry point. RCEL projects were most common and included several larger TTS projects implemented in Bangladesh, Colombia, Brazil and India. Thirty-three per cent of projects combined responsive caregiving with health interventions (typically nutrition (53%) or newborn health (37%)) (figure 3B). A smaller proportion of projects integrated interventions with other sectors (eg, maternal mental health (18%) or child protection (9%)) (figure 3B). (Since evaluation was completed, subsequent rounds of Saving Brains grants have increased emphasis and an increased number of grants focusing on children’s child protection, disability and humanitarian settings. See Archived Requests for Proposals accessible at http://www.grandchallenges.ca/programs/saving-brains/.) Twenty-five per cent was delivered in an early learning/childcare context (figure 3B).
Targeted versus universal
In line with the funder requirements, all projects were targeted on the basis of a range of developmental risk factors, including:
Health, for example, nutritional status or neonatal risk factors (ie, preterm birth or low birth weight). One project (Jamaica) for children with a non-nutritional chronic disease (ie, sickle cell disease).
Geographic location including rural, remote populations and urban slum populations.
Maternal mental health. One project (Democratic Republic of Congo) targeted women at risk of depression based on screening.
Developmental delay. One project (Peru) targeted an at-risk population based on developmental screening. No interventions explicitly focused on children with developmental disabilities.1
However, methods for targeting varied and frequently relied on implicit local knowledge in settings where population-level data on child developmental status and risk factors were lacking (supplementary web appendix table C).
Our mixed-method evaluation of the largest donor investment in ECD highlighted important findings of relevance to health professionals and policymakers around the world.
Multilevel partnerships are important for design, implementation and scaling. Our findings add to previous literature emphasising the importance of partnerships between policymakers, implementers in different sectors, communities and researchers. TTS projects built on long-term, well-established relationships with stakeholders at multiple system levels and emphasised the practical importance of leadership at lower as well as higher system levels to support implementation (eg, in KMC scaling in Cameroon and Mali, for health worker engagement in Bangladesh). TTS project experiences also highlight that roles and responsibilities within these partnerships change with scaling (eg, changing responsibilities for health worker training with scaling in Bangladesh and Colombia).18 21
Leadership for ECD can be developed through peer networks and ‘communities of practice’. We observed peer-peer learning and development of multidisciplinary communities of practice to be useful mechanisms for ECD leadership development at country level. There are an increasing number of such communities being developed, which could serve as a useful resource for policymakers and practitioners alike. For example, the Early Child Development Action Network was established by UNICEF and the World Bank in 2016 to provide one access point to resources and a community of practitioners.22 23
Situational analysis and adaptation of ECD interventions to context are crucial but often rely on implicit knowledge and informal processes. Situational analysis and formative data are crucial for intervention adaptation, feasibility, sustainability and scale-up. However, we observed that situational analysis typically relied on implicit knowledge of context rather than a systematic approach, and there were limited data on epidemiological need (ie, population-level child development status and/or risk factors). In other areas of child health (eg, newborn health), structured tools for assessment of context and availability of epidemiological data provide clearer structure for adapting interventions to context.24
There are an increasing number of tools to support situational analysis within ECD including World Bank ‘Country Profiles’ for assessing policy context and the UNICEF situational analysis tool which is available online.
A range of sectoral entry points for RCEL may be effective depending on context. TTS projects demonstrate that multiple sectors provide feasible and acceptable entry points for ECD. The Enhanced Family, Women and Infancy Program (FAMI) and Modified Reach Up (Bangladesh) programmes add to previous literature that demonstrates that RCEL interventions can be adapted and effectively implemented across diverse settings, in both cases through government services. Mobile Crèches demonstrated an alternative entry point through private and informal sectors to successfully engage hard-to-reach children.
All projects were targeted but varied in the approach used to identify their target population, often relying on informal local knowledge. While use of commonly available indicators (eg, socioeconomic data in the Enhanced FAMI programme or health status in the Modified Reach Up (Bangladesh)) is one practical approach, improved population-level data on a broader range of developmental risk factors (eg, Countdown ECD Country profiles) will enable more effective targeting of other at-risk groups, including children with disabilities.25 26
Early consideration of pathways to impact and scale is important and can be supported by a ‘theory of change’ approach. Given that ECD interventions, like those in other inherently interdisciplinary fields (eg, nutrition, mental health), are complex, inter-related and dynamic, it is important to have a programming approach that allows for this complexity, considers pathways to impact and potential challenges to scaling from early stages of design. The Saving Brains portfolio used of a theory of change approach which was valued by multiple stakeholders in encouraging forward planning. This resonates with recent literature in the field which demonstrates that RCEL interventions developed using a theory of change approach are most effective across LMIC.25
Evaluation also highlighted scaling as ongoing and adaptive rather than as a separate process that occurs only after initial demonstration of effectiveness. This finding is supported by other literature from both high-income country and LMIC which demonstrates that simple approaches to rapid cycle learning (eg, incorporation of plan-do-act cycles) can strengthen ECD programmes.6 16 27
Strengths, limitations and research implications
While this is the largest multicountry evaluation to date, Saving Brains projects were relatively small, of short duration and heterogeneous in design and quality. We now need rigorous evaluation at much larger scale and our work highlights specific gaps including how to strengthen demand; facilitation and governance of partnerships at scale; programme strategies when leadership is lacking; further development of situational tools to improve context description by epidemiology and level of service provision; differentiation of programme designs according to context; and targeted interventions including for children in humanitarian settings and with disabilities, both of which are a focus in ongoing Grand Challenges Canada funded portfolios.28–30
Improved population-level data will be important for ensuring equitable coverage to identified target populations.11 Identifying population strengths as well as risk factors in programme success will be crucial in respectful cross-cultural adaptation of interventions.6
Finally, more research to better understand cost-effectiveness of design and implementation choices is needed. Although the TTS project in Colombia provides a good example of such work and in spite of its recognised importance, many project teams were unable to address this.21 Other crucial issues discussed later in this supplement include; monitoring and evaluation, funding and accountability and barriers and enablers to scaling.11–14
ECD programme development across LMIC requires targeted situational analysis and practical approaches to incorporating feedback into design, implementation and scaling. Long-term investment in partnership at all levels is crucial as is leadership which can be supported by peer networks and ‘communities of practice’. Multiple sectoral entry points are feasible and effective at small scale but ongoing research is needed to inform how to systematically differentiate programme design according to context and to understand impact at much larger scale over longer time periods. Improved data on ECD at population level are needed to promote more effective programme targeting and tracking of coverage and equity with scale-up. Finally, approaches to addressing practical human resource challenges, defining essential intervention content, and monitoring and evaluating programmes are also needed to deliver on calls for action in ECD.
We thank all the innovators, participants and researchers involved in projects included in the Saving Brains portfolio and evaluation. We thank Grand Challenges Canada as funder of unpublished data. We thank the Early Child Development Expert Advisory Group for their guidance; and we are grateful to Claudia da Silva and Fion Hay for administrative assistance.
Contributors Technical oversight of the series was led by JEL and KMM. The first draft of the paper was undertaken by KM. Other specific contributions were made by RBS, AB, PRB, TD, MG, EG, JH, RH, BK, MKL, HK, KM, VPH, JR, MAR, KLS, CT, JEL. The Early Child Development Expert Advisory Group (PRB, TD, EG, Sally Grantham-McGregor, MG, JH, RH, KM, JR, MAR, KLS, Arjun Upadhyay) contributed to the conceptual process throughout. All authors reviewed and agreed on the final manuscript.
Funding This supplement has been made possible by funding support from the Bernard van Leer Foundation. Saving Brains impact and process evaluation was funded by Grand Challenges Canada.
Disclaimer The authors alone are responsible for the views expressed in this article and they do not necessarily represent the views, decisions or policies of the institution with which they are affiliated.
Competing interests None declared.
Provenance and peer review Commissioned; externally peer reviewed.
Data sharing statement All data within this research article are covered by a data sharing agreement as part of the Saving Brains, Grand Challenges Canada, grant with Saving Brains and other individual project teams. We are happy to provide further details on request.