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Fluid resuscitation with unbuffered electrolyte solutions may cause harm and their use should be cautioned

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The FEAST study [Maitland K, et al. N Engl J Med 2011; 364: 2483–95) has created massive debate in the paediatric critical care world. Volume bolus fluid resuscitation was compared with maintenance fluids alone in more than 3000 children with fever and clinical signs of impaired perfusion and shock. The trial was stopped because of increased mortality in the bolus groups. The study group have now gone back to the original data set to explore possible reasons for this excess mortality. Levin ML et al. (Lancet Respir Med …

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