Table of contents

European Society for Developmental Perinatal and Paediatric Pharmacology Congress, Basel, 28–30 May 2019

Oral Presentations

• O01 Drug-related hospital admissions in paediatrics – what is preventable? (17 May, 2019) Free

  I Toni, S Wimmer, R Trollmann, W Rascher, A Neubert
• O02 Developmental pharmacogenetics of SLCO2B1 on montelukast pharmacokinetics in chinese children (17 May, 2019) Free

  Q Li, K Wang, H-Y Shi, Wu Y-E, Y Zhou, M Kan, Y Zheng, G-X Hao, X-M Yang, Y-L Yang, Su L-Q, X-L Wang, E Jacqz-Aigrain, W Zhao
• O03 Allergy to penicillins in a pediatric population: reported vs true (17 May, 2019) Free

  AA Elzagallaai, H Gill, MJ Rieder
• O04 Fetal Outcome following Dydrogesterone Exposure in Pregnancy (17 May, 2019) Free

  G Koren, D Gilboa
• O05 Physiologically based pharmacokinetic modelling to characterize acetaminophen pharmacokinetics and NAPQI formation in non-pregnant and pregnant women (17 May, 2019) Free

  P Mian, JN van den Anker, K van Calsteren, P Annaert, D Tibboel, M Pfister, K Allegaert, A Dallmann
• O06 Methadone dosing strategies in preterm neonates can be simplified (17 May, 2019) Free

  T van Donge, S Samiee-Zafarghandy, M Pfister, G Koch, M Kalani, A Bordbar, J van den Anker
• O07 Predictive performance of a physiologically based pharmacokinetic model of caffeine in the preterm population (17 May, 2019) Free

  A Pansari, K Abduljalil, T Johnson
• O08 Pharmacokinetics of prophylactic and therapeutic fluconazole in preterm neonates (17 May, 2019) Free

  A Engbers, RB Flint, S Völler, IKM Reiss, KD Liem, PLJ Degraeuwe, P Andriessen, JWC Alffenaar, BCP Koch, SHP Simons, CAJ Knibbe, R Brüggemann
• O09 Drug delivery kinetics of intravenous gentamicin in a population of neonates (17 May, 2019) Free

  G Salis, N Medlicott, D Reith
• O10 Effect of hemodialysis dose (spKt/V) on survival in patients on maintenance hemodialysis since childhood – a retrospective analysis (17 May, 2019) Free

  V Gotta, A Atkinson, O Marsenic, M Pfister
• O11 Characterising the pharmacokinetics of phenobarbitone in neonates to facilitate future individualised dosing (17 May, 2019) Free

  A Williams, T Donovan, B Charles, C Staatz
• O12 Circulating concentrations of broad-spectrum beta-lactams in children with cancer: beware of glomerular hyperfiltration! (17 May, 2019) Free

  P André, L Diezi, LA Decosterd, PA Crisinel, K Dao, M Diezi, S Asner, T Buclin
• O13 Improved early vancomycin exposure in neonates using a population pharmacokinetic model-based vancomycin dosing regimen (17 May, 2019) Free

  A Smits, E De Saeger, A Vandendriessche, V Cossey, K Allegaert
• O14 Paternal acitretin exposure and pregnancy risks (17 May, 2019) Free

  M Nørgaard, JT Andersen
• O15 Lidocaine plasma concentrations and anti-epileptic efficacy in term and preterm neonates: prospective validation of a new dosing regimen (17 May, 2019) Free

  L Favié, C Rademaker, M van den Broek, T Egberts, F van Bel, F Groenendaal
• O16 Piglets as animal model to assess the contribution of fluid therapy to the development of augmented renal clearance in children (17 May, 2019) Free

  L Dhondt, S Croubels, P De Paepe, P De Cock, M Devreese
• O17 The bioavailability and maturing clearance of doxapram in preterm infants (17 May, 2019) Free

  RB Flint, SHP Simons, P Andriessen, KD Liem, PLJ Degraeuwe, IKM Reiss, R Ter Heine, AGJ Engbers, BCP Koch, R De Groot, DM Burger, CAJ Knibbe, S Völler, DINOResearch Group
• O18 Therapeutic delivery during breastfeeding: a feasibility study (17 May, 2019) Free

  T Maier, P Peirce, L Baird, SL Whitehouse, NKH Slater, K Beardsall
• O19 Development of a paediatric brain PBPK model in children with and without meningitis (17 May, 2019) Free

  LFM Verscheijden, JB Koenderink, K Allegaert, SN de Wildt, FGM Russel
• O20 Dose-linearity of the pharmacokinetics of an intravenous [¹⁴C]midazolam microdose in children

  (17 May, 2019) Free

  BD van Groen, WHJ Vaes, BK Park, EHJ Krekels, E van Duijn, L-T Kõrgvee, W Maruszak, G Grynkiewicz, RC Garner, C Knibbe, D Tibboel, SN de Wildt, MA Turner
• O21 Progress towards Therapeutic Drug Monitoring via breath analysis (17 May, 2019) Free

  KD Singh, V Ziesenitz, J Usemann, J Van Den Anker, U Frey, N von der Weid, A Datta, P Sinues
• O22 3D printed polyethylene oxide oral doses with innovative ‘radiator-like’ design: impact of molecular weight on mechanical and rheological properties and drug release (17 May, 2019) Free

  M Peak, K Baj, A Isreb, M Wojsz, I Mohammad, M Albed Alhnan
• O23 Can children swallow tablets? outcome data from a feasibility study to assess the swallowability and acceptability of different sized placebo tablets in children and young people (creating acceptable tablets – cat) (17 May, 2019) Free

  L Bracken, E McDonough, S Ashleigh, F Wilson, U Ohia, P Mistry, H Jones, N Kanji, F Liu, M Peak
• O24 Ivermectin in children: what is the right dose to achieve equivalent exposure coverage in children and adults? (17 May, 2019) Free

  JM Brussee, JD Schulz, JT Coulibaly, J Keiser, M Pfister
• O25 Clavulanate stability in child-appropriate formulations is inadequate for use in treating young children in Asia (17 May, 2019) Free

  I Mack, M Sharland, S Rehm, K Rentsch, J Bielicki
• O26 Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young Infants (17 May, 2019) Free

  E Jacqz-Aigrain, S Leroux, AH Thomson, K Allegaert, EV Capparelli, V Biran, N Simon, B Meibohm, Lo Y-L, R Marqués, J-E Peris, I Lutsar, J Saito, H Nayamura, JN van den Anker, M Sharland, W Zhao
• O27 Prospective evaluation of a population pharmacokinetic model of pantoprazole for obese children (17 May, 2019) Free

  A Chapron, S Abdel-Rahman, V Shakhnovich
• O28 Variability in liver anatomy and physiology in children participating in pharmacokinetic studies (17 May, 2019) Free

  A Friesen, J Radford, S Chan, N Mardis, V Shakhnovich
• O29 Pharmacometric modelling of free thyroxine dynamics after initiation of antithyroid drug treatment in children with Graves’ disease: a tool for personalized drug dosing in children (17 May, 2019) Free

  G Koch, V Gotta, C Ollagnier, D Konrad, C Flück, D L’Allemand, M Steigert, A Rohner, F Bachmann, J Schropp, G Szinnai, M Pfister
• O30 A comprehensive analysis of ontogeny of renal drug transporters: mRNA analyses, quantitative proteomics and localization (17 May, 2019) Free

  KWK Cheung, BD van Groen, E Spaans, MD van Borselen, ACJM de Bruijn, Y Simons-Oosterhuis, D Tibboel, JN Samsom, RM Verdijk, B Smeets, L Zhang, S-M Huang, KM Giacomini, SN de Wildt
• O31 Levetiracetam monitoring in breast-milk: high inter-individual variability (17 May, 2019) Free

  N Dinavitser, E Kohn, M Berlin, A Livne, R Keidar, L Ben-Nun, N Agajani, R Sheinberg, S Gamsu, H Flor-Hirsch, N Brandriss, A Bar-Chaim, D Stepenski, M Berkovitch
• O32 Ontogeny of human kidney OCT2 expression across the paediatric age range (17 May, 2019) Free

  N Smeets, B van Groen, J Pertijs, M Wilmer, B Smeets, R Verdijk, S de Wildt
• O33 Towards personalised weaning of sedatives and analgesics using mechanism-based modelling of iatrogenic withdrawal in critically ill children (17 May, 2019) Free

  S Goulooze, E Krekels, M van Dijk, T Hankemeier, D Tibboel, E Ista, C Knibbe
• O34 Item response theory modeling; old kid on the block to improve pediatric drug dosing (17 May, 2019) Free

  EHJ Krekels, PAJ Välitalo, SC Goulooze, T de Kluis, M van Dijk, SHP Simons, D Tibboel, CAJ Knibbe
• O35 Midazolam pharmacokinetics in children with obesity (17 May, 2019) Free

  C Gade, E Sverrisdóttir, K Dalhoff, J Sonne, H Rolighed Christensen, J Burhenne, G Mikus, J-C Holm, T Meldgaard Lund, H Holst
• O36 Physiologically based pharmacokinetic models to predict fetal exposure to antiviral drugs (17 May, 2019) Free

  X Liu, J Momper, N Rakhmanina, J van den Anker, D Green, G Burckart, B Best, M Mirochnick, E Capparelli, A Dallmann
• O37 Use of albendazole in children with asymptomatic toxocariasis (17 May, 2019) Free

  F Garcia Bournissen, S Moroni, N Gonzalez, G Moscatelli, G Ballering, J Altcheh
• O38 Population pharmacokinetics of ganciclovir after oral valganciclovir in renal transplant children (17 May, 2019) Free

  A Facchin, V Elie, N Benyoub, V Baudouin, A Maisin, S Magreault, E Jacqz-Aigrain
• O39 Defining serum CCL22 and trefoil factor 3 (TFF3) as pharmacodynamic biomarkers for use in a proof-of-concept clinical trial of vamorolone in paediatric ulcerative colitis (17 May, 2019) Free

  LS Conklin, A Panigrahi, H Gordish-Dressman, EP Hoffman, Y Hathout, JN van den Anker, L Diaz-Calderon

Poster Presentations

• P01 Application of feto-placental-maternal physiologically-based pharmacokinetic model to predict tenofovir concentration during pregnancy (17 May, 2019) Free

  K Abduljalil, TN Johnson, M Jamei
• P02 Allopurinol counteracts inadequate mercaptopurine metabolism in paediatric acute lymphoblastic leukemia (17 May, 2019) Free

  T Adam de Beaumais, A Petit, M Simonin, Y Médard, A Benchikh, C Dollfus, G Leverger, E Jacqz-Aigrain
• P03 Germline NUDT15 mutation and thiopurines for children with acute lymphoblastic leukemia: is it a prognostic factor?

  (17 May, 2019) Free

  M Simonin, A Petit, Y Médard, A Benchikh, O Minckes, A Auvrignon, J Donadieu, G Leverger, E Jacqz-Aigrain, T Adam de Beaumais
• P04 Non-compartmental analysis of vancomycin pharmacokinetics in critically ill children (17 May, 2019) Free

  O Akunne, P Mugabo, A Argent
• P05 Establishing the integrity of the continually paediatric pharmacokinetic bioanalysis for clinical trial within an academia environment using quality assessment process (17 May, 2019) Free

  M Ali, J Tins, BB Burckhardt
• P06 Paternal exposure to methotrexate and the risk of miscarriage – a register based nationwide cohort study (17 May, 2019) Free

  J Andersen, B Askaa, TB Jensen, H Horwitz, C Vermehren, K Broedbaek
• P07 Roxithromycin in early pregnancy and the risk of major congenital malformation: a register based nationwide cohort study (17 May, 2019) Free

  RH Olsen, HE Poulsen, JT Andersen
• P08 Is there a difference in the frequency of manipulated orally and rectally administered medicines to paediatric in-patients in Sweden in the year 2009 and 2018 respectively? A register study (17 May, 2019) Free

  A Andersson, S Eksborg, S Lindemalm, U Förberg
• P09 Serum neurofilament light chain levels are an independent predictor of neurodevelopmental outcome in preterm infants (17 May, 2019) Free

  A Hauck, K Goeral, A Atkinson, R Fuiko, C Leeb, Z Michalak, K Klebermass, J van den Anker, A Berger, J Kuhle, M Olischar, S Wellmann
• P10 Reporting of offspring data in diabetes, HIV infection and hypertension trials during pregnancy: a systematic review (17 May, 2019) Free

  B Aurich, T Martin-Montoya, D Zhang, E Jacqz-Aigrain
• P11 Neonatal and paediatric protocol development and drug safety: points to consider for risk management and safety data collection (17 May, 2019) Free

  B Aurich, V Elie, E Jacqz-Aigrain
• P12 Public antibiotic awareness campaign organised by government significantly reduced inappropriate antibiotic use in paediatric primary care settings (17 May, 2019) Free

  M Bajcetic, M Lazic, I Lukic, D Rajkovic
• P13 Serious adverse reactions and off label and unlicensed drug use in children – decade of pharmacovigilance study in Serbia (17 May, 2019) Free

  M Bajcetic, J Joksimovic
• P14 Pharmacovigilance in pediatric patients: the challenge of identifying new signal (17 May, 2019) Free

  N Kronenfeld, S Gamsu, H Flor-Hirsch, N Agajani, R Sheinberg, L Ben-Nun, M Goldman, M Berkovitch
• P15 Lacosamide monitoring in the serum of children with refractory epilepsy (17 May, 2019) Free

  N Kronenfeld, E Kohn, M Lezinger, N Brandriss, E Heyman, A Bar-Chaim, M Berkovitch
• P16 Towards determination of endogenous prorenin in paediatric samples using a hybrid approach – impact of antibody selection for immunocapture (17 May, 2019) Free

  I Burdman, BB Burckhardt
• P17 Clinical evidence supported by a model-based approach and real world data for the development of c.e.r.a. (continuous erythropoietin receptor activator) in pediatric patients with anemia due to chronic kidney disease (17 May, 2019) Free

  P Chanu, A Weichert, F Schaefer, S Meyer Reigner, B Reigner, N Frey
• P18 Appropriateness of antibiotic prescriptions for children and adolescents attending emergency departments for pharyngotonsillitis (17 May, 2019) Free

  F Messina, A Clavenna, M Cartabia, A Bortolotti, I Fortino, L Merlino, M Bonati
• P19 Drug use in adolescents attending the emergency department for mental health problems (17 May, 2019) Free

  M Buttera, A Clavenna, E Maselli, L Tansini, MP Canevini, M Bonati
• P21 PBPK modeling in pregnancy: achievements, shortcomings and future perspectives (17 May, 2019) Free

  A Dallmann, P Mian, P Annaert, M Pfister, K Allegaert, J van den Anker
• P22 ADME properties of vamorolone, a first-in-class dissociative steroidal anti-inflammatory drug (17 May, 2019) Free

  JM Damsker, Y Piyis, LA Peña, JM McCall
• P23 Evaluation of exposure to vancomycin in neonates with current dosing approaches (17 May, 2019) Free

  K Dao, M Guidi, P Andre, E Giannoni, A Fuchs, M Pfister, T Buclin, C Csajka
• P24 Caffeine in preterm neonates: impact on sleep wake regulation (17 May, 2019) Free

  AN Datta, G Koch, N Schönfeld, K Jost, A Atkinson, SM Schulzke, M Pfister
• P25 Comparison of renal function estimation methods in critically ill children: a pilot study (17 May, 2019) Free

  E Dhont, T Van Der Heggen, A De Jaeger, J Willems, S De Baere, S Croubels, J Vande Walle, P De Paepe, P De Cock
• P26 Pilot on harmonising dosing recommendation for term and preterm neonates in the Netherlands (Neodose project) (17 May, 2019) Free

  MA de Hoop-Sommen, TM van der Zanden, K Allegaert, RB Flint, SHP Simons, SN de Wildt, NeoDose Consortium
• P27 The juvenile pig as animal model for unraveling renal drug elimination processes in children (17 May, 2019) Free

  L Dhondt, S Croubels, P De Paepe, P De Cock, M Devreese
• P28 Pharmacokinetics and implications for drug dosing in children with sickle cell disease: a systematic review (17 May, 2019) Free

  N Dia, J Autmizguine, Y Pastore, C Litalien, A Rémy, M Amélie, Y Théorêt, N Kleiber
• P29 A smartphone application to monitor nausea in pediatric cancer patients during chemotherapy (17 May, 2019) Free

  A Eliasen, MK Abildtoft, NS Krogh, JS Brok, R Mathiasen, K Schmiegelow, KP Dalhoff
• P30 Limited sampling strategies to predict valganciclovir exposure in kidney transplanted children (17 May, 2019) Free

  N Benyoub, A Facchin, S Magreault, E Jacqz-Aigrain, V Elie
• P31 No interaction between doxapram and caffeine for the treatment of preterm neonates with apnea (17 May, 2019) Free

  A Engbers, N Dia, S Völler, CAJ Knibbe, IKM Reiss, BCP Koch, RB Flint, SHP Simons
• P32 Depiction of haematological and biochemical laboratory normal reference values in a European multicentre paediatric trial (17 May, 2019) Free

  S Farahani, E Feles, BB Burckhardt, S Laeer, on behalf of the LENA consortium
• P33 Effectiveness of OSCEs in training German pharmacy students in consultation on self-medication – a randomised controlled investigation (17 May, 2019) Free

  I Farahani, A Laven, S Farahani, MA Deters, M Feickert, FK Suessenbach, H Schwender, S Laeer
• P34 Reliable results in continuous bioanalysis of paediatric renin samples – comprehensive quality assessment within clinical studies in children (17 May, 2019) Free

  M Feickert, I Burdman, N Makowski, M Ali, S Farahani, H Majid, AM Ciplea, A Bartel, BB Burckhardt
• P35 Aprepitant in the prevention of cardiotoxic adverse effects of Doxorubicin in the paediatric population – a systematic literature investigation (17 May, 2019) Free

  M Feickert, BB Burckhardt
• P36 What can be learnt from serious drug related medical errors in pediatric patients in Gothenburg 2015–2017? (17 May, 2019) Free

  S Fjeldseth
• P37 Reference ranges of blood NT-proBNP in paediatric heart failure and healthy controls: compilation of literature data (17 May, 2019) Free

  T Gangnus, FK Suessenbach, N Makowski, I Burdman, S Laeer, BB Burckhardt
• P38 Identification of Nifurtimox metabolites in urine of pediatric Chagas disease patients by UHPLC-MS/MS (17 May, 2019) Free

  CA Pérez Montilla, S Moroni, N González, G Moscatelli, JM Altcheh, F García Bournissen
• P39 Establishment of the swiss database for dosing medicinal products in pediatrics (17 May, 2019) Free

  E Giger, A Glauser, D Panis, R Tilen, C Berger
• P40 Comparison of antibiotic consumption between pediatric hospitals (17 May, 2019) Free

  H-J Gober
• P41 Prenatal exposure to antibiotics and development of epilepsy in children (17 May, 2019) Free

  R Gorodischer, N Sassonker- Joseph, M Atar-Vardi, I Noyman, L Novak
• P42 External validation of model-based dosing guidelines for vancomycin, gentamicin and tobramycin in critically ill children (17 May, 2019) Free

  S Hartman, S Zwaag, L Orriëns, T Poel, M de Hoop - Sommen, S de Wildt
• P43 Pharmacokinetics and target attainment of antibiotics in critically ill children – a systematic review of current literature (17 May, 2019) Free

  S Hartman, R Brüggemann, L Orriëns, N Dia, M Schreuder, S de Wildt
• P44 Type 2 diabetes mellitus in children: non-insulin medication, where are we up to? (17 May, 2019) Free

  R Austin, P Paul, D Hawcutt
• P45 The acceptability of using genetic information to guide treatment of asthma to children, young people, and parents (pilot study) (17 May, 2019) Free

  C King, L Bracken, E McDonough, M Pirmohamed, M Peak, D Hawcutt
• P46 Spontaneous reporting of suspected adverse drug reactions by children and young people: past, present and future (17 May, 2019) Free

  C King, N Bhoombla, J Clarke, V Morgan, J Preston, J Ainsworth, A Hanson, D Hawcutt
• P47 Prevalence, incidence and patterns of antiasthma medication use in children: a nationwide prescription study in France (17 May, 2019) Free

  I Naim, F Tubach, S Guillo, A Ajrouche, Y De Rycke, F Kaguelidou
• P48 Prescribing patterns of antiasthma medication in children and adolescents in primary care in france (17 May, 2019) Free

  I Naiim, F Tubach, S Guillo, A Ajrouche, V Houdouin, Y De Rycke, F Kaguelidou
• P49 A pharmacokinetic evaluation of oral clavulanic acid in term newborns (17 May, 2019) Free

  FM Keij, RF Kornelisse, NG Hartwig, J van der Sluijs, A van Driel, S Kenter, J Heidema, P den Butter, BCP Koch, IKM Reiss, K Allegaert, GA Tramper-Stranders
• P50 Individual variations in fentanyl pharmacokinetics and pharmacodynamics in preterm infants (17 May, 2019) Free

  J Kindblom, E Norman, A Rane, A-C Berg, U Schubert, B Hallberg, V Fellman
• P51 A combined experimental approach to assess intestinal drug absorption in early childhood (17 May, 2019) Free

  M Kiss, J Nicolaï, JJMW van den Heuvel, R Mbasu, SM Botden, JB Koenderink, FGM Russel, A-L Ungell, SN de Wildt
• P52 Low and erratic exposure of oral acetaminophen in critically ill children determined with a ¹⁴C microtracer study: a case for IV acetaminophen for acute pain management?

  (17 May, 2019) Free

  N Kleiber, E Calvier, MG Mooij, EHJ Krekels, WH Vaes, AD Windhorst, H Hendrikse, D Tibboel, CAJ Knibbe, SN de Wildt
• P53 Exposure of infants to brominated flame retardants through breast-milk (17 May, 2019) Free

  E Kohn, S Efreim, R Lubetzky, D Mandel, R Marom, M Betser, R Keidar, A Livne, A Levy, P Factor-Litvak, S Soback, M Britzi, M Berkovitch
• P54 KIDS-STEP: a swiss multi-centre RCT on effectiveness of adjunct betamethasone therapy in hospitalised children with community acquired pneumonia (17 May, 2019) Free

  M Kohns Vasconcelos, R Santoro, M Coslovsky, J van den Anker, JA Bielicki
• P55 Preventing inappropriate hydroxyurea dosing in children by introducing a child-appropriate preparation (17 May, 2019) Free

  G Koren
• P56 Breakthrough in the treatment of nausea and vomiting of pregnancy; the first dual release combination of doxylamine-pyridoxine (17 May, 2019) Free

  G Koren
• P57 Filling the gap for children with heart failure: the EU-funded drug development program LENA (labeling of enalapril from neonates up to adolescents) (17 May, 2019) Free

  S Laeer, J Breitkreutz, I Klingmann, F Lagler, M Dalinghaus, M Bajcetic, S de Wildt, AK Clark, H Breur, C Male, I Jovanovic, M Djukic, TS Mir, A Szatmári, V Vukomanović, L Ablonczy, BB Burckhardt, W Cawello, K Kleine, E Obarcanin, L Spatenkova, V Swoboda, M Van der Meulen, P Wagner, J Walsh, on behalf of the LENA consortium
• P58 Development of JUNIORMED – the Austrian paediatric pharmacopoeia (17 May, 2019) Free

  F Lagler, P Hofbauer, L Danninger, B Hattinger, M Aichberger, U Mursch-Edlmayr, W Sperl
• P59 Monitoring the recovery time of children after elective tonsillectomies using commercial activity trackers, an prospective feasibility study (17 May, 2019) Free

  PIP Lambrechtse, VC Ziesenitz, A Atkinson, EJ Bos, T Welzel, Y Gilgen, N Gürtler, AF Cohen, JN Van Den Anker
• P60 Serum Creatinine is superior to Serum Cystatin C in explaining inter-individual variability of vancomycin clearance in neonates and young infants (17 May, 2019) Free

  S Leroux, V Biran, J van den Anker, W Zhao, E Jacqz-Aigrain, M Pfister
• P61 Population pharmacokinetics of vancomycin in chinese ICU neonates: initial dosage recommendations (17 May, 2019) Free

  Z Li, Z Jiao
• P62 Population pharmacokinetic study of aminophylline in Indian preterm neonates (≤34weeks) with apnoea; a longitudinal observational study (17 May, 2019) Free

  S M, L Lewis, S Mallayasamy
• P63 UPLC/MS/MS assay for the simultaneous determination of seven antibiotics in human serum – application to pediatric studies (17 May, 2019) Free

  S Magreault, O Chaussenery-Lorentz, T Storme, E Jacqz-Aigrain
• P64 Quality assessment for the continuous bioanalysis of aldosterone: application in an European paediatric study (17 May, 2019) Free

  N Makowski, I Burdman, M Ali, H Majid, S Farahani, AM Ciplea, A Bartel, BB Burckhardt
• P65 Differentiating alprostadil associated fever from infectious fever: a retrospective case-control study of neonates with ductus dependent congenital heart disease in a Tertiary Care Center (17 May, 2019) Free

  R Masarwa, S Soskin, A Vardi, G Paret, I Matok
• P66 Characterization of the pharmacokinetics of acetaminophen and its metabolites in the fetus through integration of placental transfer in a physiologically based pharmacokinetic model (17 May, 2019) Free

  P Mian, K Allegaert, S Conings, P Annaert, D Tibboel, M Pfister, K van Calsteren, JN van den Anker, A Dallmann
• P67 Impact of enantiomer-specific maturational changes in pharmacokinetics on the racemic ketorolac target trough concentration (17 May, 2019) Free

  M Cloesmeijer, E Krekels, M van Esdonk, A Lynn, A Smits, D Tibboel, Y Daali, K Olkkola, K Allegaert, P Mian
• P68 Significant oral drug use in critically ill children: rational therapy or a black box? (17 May, 2019) Free

  M Mooij, J Windster, J van Rosmalen, L Hanff, D Tibboel, S de Wildt
• P69 Pharmacokinetics of a continuous infusion of piperacillin/tazobactam to children using an elastomeric pump (POPPET Study): pilot data from double lumen central lines (17 May, 2019) Free

  J Moss, V Price, S Paulus, V Ramos-Martin, A Melaine, E Evans, P Newland, W Hope, D Hawcutt, B Pizer
• P70 Identifying and managing problematic polypharmacy in children and young people? (17 May, 2019) Free

  J Moss, R Austin, D Hawcutt
• P71 Population pharmacokinetics and pharmacogenetics of caffeine in Chinese premature infants with apnoea of prematurity (17 May, 2019) Free

  S Ni, X-B Gao, Hu Y-E, C-H Wang, Z-H Jiang, F Yang, Y Zheng, W Zhao
• P72 Maturation of sildenafil clearance in prematurely born infants with BPD associated pulmonary hypertension (17 May, 2019) Free

  H Nikrawesh, AGJ Engbers, S Völler, SHP Simons, BCP Koch, CAJ Knibbe, IKM Reiss, RB Flint
• P73 Paediatric population pharmacokinetic modeling for gentamicin – is the current dose recommendation justified? (17 May, 2019) Free

  P Paioni, C Berger, SD Krämer
• P74 Rituximab effect on B cell depletion in paediatric patients with autoimmune diseases: a retrospective dose-response analysis of an observational study (17 May, 2019) Free

  S Pan, H Yu, A Surti, I Cheng, SD Marks, PA Brogan, D Eleftheriou, JF Standing
• P75 Relation between polymorphism of folic acid cycle genes and effectiveness of methotrexate in children with juvenile idiopathic arthritis (17 May, 2019) Free

  N Panko
• P76 The effect of the pregnancy and lactation labeling rule on prescribing information of FDA-approved drugs (17 May, 2019) Free

  A Patel, M Mazer-Amirshahi, G Fusch, A Chan, J van den Anker, S Samiee-Zafarghandy
• P77 Pediatric drug data in Canadian drug monographs (17 May, 2019) Free

  A Patel, M Duffett, M Mazer-Amirshahi, P Raja, A Chan, J van den Anker, S Samiee-Zafarghandy
• P78 Pharmacokinetics of intravenous and intranasal nalbuphine in infants (17 May, 2019) Free

  M Pfiffner, V Gotta, E Berger-Olah, M Pfister, P Vonbach
• P79 Pharmacokinetics of sufentanil in critically ill neonates (17 May, 2019) Free

  P Pokorná, M Šíma, B Koch, D Tibboel, O Slanař
• P80 Objective pharmacodynamic evaluation of doxapram in preterm infants (17 May, 2019) Free

  JA Poppe, W van Weteringen, S Völler, TG Goos, IKM Reiss, SHP Simons
• P81 Use of systemic antibiotics in Austrian children and adolescents: a survey (17 May, 2019) Free

  E Rauch, FB Lagler, H Herkner, V Strenger, C Male
• P82 Is busulfan clearance different in patients with sickle cell disease (SCD) compared to patients without sickle cell disease? (17 May, 2019) Free

  A Remy, Y Théorêt, M Ansari, H Bittencourt, T Ducruet, M Krajinovic, T Nava, Y Pastore, MA Rezgui, N Kleiber
• P83 CYP2D6 phenotyping in children treated with tramadol at the Emergency Department (17 May, 2019) Free

  F Rodieux, F Storelli, S Manzano, A Gervaix, K Posfay-Barbe, C Samer, Y Daali, J Desmeules
• P84 Pediatric oncology studies triggered by the united states (US) food and drug administration (FDA) and the european union (EU) european medicines agency (EMA) aim at labels, not at improved treatment. Some harm young patients by exposing them to substandard monotherapy instead of combination treatment (17 May, 2019) Free

  K Rose
• P85 Prediction of raltegravir plasma concentration in HIV paediatric patients using physiologically-based pharmacokinetic model (17 May, 2019) Free

  F Salem, K Abduljalil, T Johnson
• P86 Treatment modalities in peripheral facial nerve palsy in children and adolescents (17 May, 2019) Free

  J Samardzic, B Kukolj, M Jovanovic, O Djuric, J Jancic
• P87 The Swiss Association of Perinatal Pharmacology, SAPP: goals (17 May, 2019) Free

  L Schenkel, U von Mandach, The Editorial Board of the SAPP
• P88 The potential impact of hematocrit correction on evaluation of tacrolimus target exposure in pediatric kidney transplant patients (17 May, 2019) Free

  A Schijvens, F van Hesteren, M Cornelissen, C Bootsma-Robroeks, R Brüggemann, D Burger, S de Wildt, M Schreuder, R ter Heine
• P89 Emicizumab development in paediatric patients with congenital hemophilia A and inhibitors against factor VIII (17 May, 2019) Free

  C Schmitt, K Yoneyama, T Chang, S Retout, H -P Grimm, GG Levy
• P90 Neuropsychiatric disorder and Montelukast: a case report and VigiBase® analysis (17 May, 2019) Free

  I Scholz, S Banholzer, M Haschke
• P91 Real-time breath analysis of antiepileptic drugs (17 May, 2019) Free

  KD Singh, V Ziesenitz, J Usemann, U Frey, J van den Anker, A Datta, P Sinues
• P92 Metabolomics in children with heart failure using ACE-inhibitors, an exciting opportunity? (17 May, 2019) Free

  N Smeets, M Dalinghaus, S de Wildt
• P93 Semi-mechanistic modelling of hydrocortisone pharmacokinetics in paediatric patients with adrenal insufficiency (17 May, 2019) Free

  V Stachanow, J Melin, R Michelet, O Blankenstein, U Neumann, R Ross, M Whitaker, W Huisinga, C Kloft
• P94 Reliable acquisition of plasma renin activity in the maturating renin-angiotensin-aldosterone-system by a validated small-volume assay in context of the LENA project (17 May, 2019) Free

  FK Suessenbach, M Feickert, J Tins, BB Burckhardt
• P95 Compilation of available plasma renin activity levels in the healthy and cardiac diseased paediatric population (17 May, 2019) Free

  FK Suessenbach, T Gangnus, I Burdman, N Makowski, S Laeer, BB Burckhardt
• P96 Preliminary results on the study to identify the relation between midazolam concentrations and level of sedation in critically mechanically ventilated children (17 May, 2019) Free

  PJ Upadhyay, NJ Vet, SC Goulooze, EHJ Krekels, SN de Wildt, CAJ Knibbe
• P97 Busulfan/sulfolane metabolic ratio on the third day of conditioning may predict the event-free survival in children receiving busulfan based conditioning prior to hematopoietic stem-cell transplantation (17 May, 2019) Free

  CRS Uppugunduri, MA Rezgui, CP Huezo-Diaz, T Nava, S Mlakar, Y Théoret, H Bittencourt, M Krajinovic, M Ansari
• P98 Semi-quantification and localization of membrane transporters in paediatric kidney tissue (17 May, 2019) Free

  M van Borselen, B van Groen, J Pertijs, M Wilmer, B Smeets, R Verdijk, S de Wildt
• P99 Clinical validation of published vancomycin population PK models in critically ill neonates (17 May, 2019) Free

  A van der Veen, RJ Keizer, W de Boode, A Somers, R Brüggemann, R ter Heine, P De Cock
• P100 A practical framework for the assessment of risks and benefits of off-label prescribing in paediatrics (ARBOP-P) (17 May, 2019) Free

  TM Van der Zanden, NJ Vet, SN de WIldt
• P101 Extending the Dutch Paediatric Formulary across Europe: successful development of country specific, parallel, paediatric drug formularies (17 May, 2019) Free

  T Van der Zanden, A Neubert, J Zahn, S Wimmer, M de Hoop, T Rosness, C Kjeldby-Høie, A Teigen, C Male, E Rauch, F Lagler, W Rascher, S de Wildt
• P102 Alternative splicing of the SLCO1B1 transporter in paediatric liver (17 May, 2019) Free

  BD van Groen, C Bi, R Gaedigk, V Staggs, D Tibboel, SN de Wildt, JS Leeder
• P103 Target attainment of amikacin therapy in critically ill children (17 May, 2019) Free

  J Verbruggen, K Jakipbayeva, T Van Der Heggen, E Dhont, L Dhondt, J Vande Walle, P De Paepe, I Herck, P De Cock
• P104 Pharmacologic differences of adalimumab, infliximab and etanercept: do we need specific vaccination recommendations for prenatally exposed infants? (17 May, 2019) Free

  T Welzel, V Gotta, N Rakhmanina, JN van den Anker
• P105 Ambulatory study center at the University of Basel Children’s Hospital (UKBB) (17 May, 2019) Free

  C Werner, R Santoro, J Bielicki
• P106 Impact of a computerised physician order entry system on medication safety in paediatrics (17 May, 2019) Free

  S Wimmer, I Toni, R Trollmann, W Rascher, A Neubert
• P107 How significant is the lack of formulations for paediatric inpatients? (17 May, 2019) Free

  J Zahn, W Rascher, A Neubert
• P108 Pharmacokinetics of mycophenolic acid for systemic lupus erythematosus in children (17 May, 2019) Free

  D Zhang, V Elie, S Magreault, I Melki, V Baudouin, E Jacqz-Aigrain
• P109 Optimal dosing regimen of caspofungin in children: milligram per kilogram or milligram per square meter? (17 May, 2019) Free

  X-M Yang, S Leroux, T Storme, D-L Zhang, T Adam de Beaumais, H-Y Shi, Y-L Yang, X-L Wang, W Zhao, E Jacqz-Aigrain
• P110 Population pharmacokinetics and dosing optimisation of imipenem in children with haematological malignancie (17 May, 2019) Free

  L Dong, X-Y Zhai, Y-L Yang, L Wang, Y Zhou, H-Y Shi, B-H Tang, Wu Y-E, F Yang, L Wen, H-X Kong, L-J Zhi, E Jacqz-Aigrain, W Zhao
• P111 Developmental pharmacogenetics of CYP2D6 in Chinese children: loratadine as a probe drug (17 May, 2019) Free

  Q Li, Wu Y-E, K Wang, H-Y Shi, Y Zhou, M Kan, Y Zheng, G-X Hao, X-M Yang, Y-L Yang, Su L-Q, X-L Wang, E Jacqz-Aigrain, W Zhao
• P112 Prediction of free Ceftriaxone concentration in children: disease and maturation do matter (17 May, 2019) Free

  H-Y Shi, X Huang, Q Li, Wu Y-E, MW Khan, Y Zhou, Y Zheng, G-X Hao, X-M Yang, Y-L Yang, E Jacqz-Aigrain, Y-M Cui, W Zhao
• P113 Population pharmacokinetics and dosing optimization of azlocillin in neonates (17 May, 2019) Free

  W Zhao, TINN-Global Study Group
• P114 Population pharmacokinetics and dosing optimization of cefepime in neonates (17 May, 2019) Free

  W Zhao, TINN-Global Study Group
• P115 Effects of the clinical pharmacist’s intervention on rationality of parenteral nutrition (17 May, 2019) Free

  M Zhu, J Xu
• P116 Prophylactic use of enoxaparin during bariatric surgery in adolescents with severe obesity (17 May, 2019) Free

  V Ziesenitz, J Vaughns, E Williams, E Nadler, G Mikus, J van den Anker
• P117 Dose evaluation of intravenous metamizole (dipyrone) in infants and children: a prospective population pharmacokinetic study (17 May, 2019) Free

  V Ziesenitz, F Rodieux, A Atkinson, C Borter, J Bielicki, M Haschke, U Duthaler, F Bachmann, T Erb, N Gürtler, S Holland-Cunz, J van den Anker, V Gotta, M Pfister
• P118 ‘Medicines for Children’ project: putting families and carers in the centre (17 May, 2019) Free

  E Zolotas, H Sammons, D Tuthill, C Barker, S Tomlin, L Partridge, A Rossiter, V Osmond, H Barham, A Fox, Medicines For Children Project Board