Statistics from Altmetric.com
A 22-day-old baby presents at your emergency department with a 3-hour history of poor feeding and fever. Blood and cerebrospinal fluid cultures reveal late-onset group B streptococcal (LOGBS) meningitis and bacteraemia. This child has a dizygotic twin who is asymptomatic. You wonder if it is necessary to test, hospitalise and give antibiotics to the asymptomatic twin?
Structured clinical question
In an asymptomatic child whose twin has an LOGBS infection (patient), is it necessary to do immediate evaluation, discontinue breast feeding and prescribe antibiotics (intervention) to avoid serious complications of group B streptococcal (GBS) disease (outcome)?
A search of the Cochrane Library using the terms ‘group B streptococcal infection’ and ‘twins’ was used.
MEDLINE was searched via PubMed from 1976 to August 2018. The advanced search mode was used with the terms ‘late-onset neonatal infection’, ‘twins’, ‘group B streptococcus’. Additional studies were found following the review of the references of articles. A total of 13 articles (case series or case reports) reporting LOGBS infections in twins were found (see table 1).
GBS remains a serious pathogen in young infants. Among bacteria responsible for invasive infections before 3 months of age, GBS represents the leading cause of meningitis1 2 and the second cause of bacteraemia.1–3 Intrapartum antibiotic prophylaxis produced a spectacular decrease in incidence of early-onset GBS disease,4–6 but has no effect in incidence of LOGBS disease.6–11 Despite advances in intensive care, case-fatality …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.