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Coeliac disease in children with Down syndrome in Ireland
  1. Mohamed Alsaffar1,
  2. Joanne Balfe1,2,
  3. Fiona McGrane1,2,
  4. Montasser Nadeem1,2,
  5. Shoana Quinn1,2,
  6. Eleanor Molloy1,2
  1. 1 Discipline of Paediatrics and Child Health, Trinity College Dublin, Dublin, Ireland
  2. 2 Department of Paediatrics, Tallaght Hospital, Dublin, Ireland
  1. Correspondence to Dr Mohamed Alsaffar, Discipline of Paediatrics and Child Health, Trinity College Dublin, Dublin, Ireland; alsaffam{at}tcd.ie

https://doi.org/10.1136/archdischild-2018-314846

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    Down syndrome (DS) is one of the most common chromosomal abnormalities with an incidence of 1:444 births.1 Ireland has the highest prevalence of DS in Europe, which may be partially explained by the legislation against termination of pregnancy.1 Individuals with DS are at higher risk of developing coeliac disease (CD) compared with the general population (5%–10% vs 1%).2

    CD can be difficult to diagnose due to the frequency of asymptomatic cases, and it can be particularly difficult to identify clinically in children with DS in whom short stature, abdominal distension and constipation are common clinical features. The European Society …

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    Footnotes

    • Competing interests None declared.

    • Ethics approval Ethical approval was obtained from Tallaght Hospital Ethics Committee.

    • Provenance and peer review Not commissioned; externally peer reviewed.