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The fetal repercussions of Zika virus (ZIKV) infection during pregnancy is of interest for maternal and child health.1 Studies on the psychomotor and neurodevelopment of children exposed in utero to arboviruses, especially non-microcephalic children, are lacking. At a maternity university hospital in Brazil, we started following the development of children, without microcephaly, born to mothers infected with ZIKV during pregnancy, searching for early warning signs of abnormalities. A normal head circumference for term newborns was defined, according to the 2016 WHO recommendation, as higher than 31.9 cm for boys and higher than 31.5 cm for girls.2 We used the Alberta Infant Motor Scale for the evaluation of motor development, and the Denver II test for tracking development in personal/social, fine motor/adaptive, language …
Contributors HCF, RdSdS and AJLAdC conceived, designed and supervised the study. TFC, RMC, JVC, CCT and RdBS undertook recruitment of patients and data collection. AP-B provided statistical advice on study design, and all authors analysed the data. TFC and HCF drafted the manuscript, and all authors contributed substantially to its revision. HCF takes responsibility for the paper as a whole.
Competing interests None declared.
Patient consent Not required.
Ethics approval The study was approved by the Institutional Review Board of Maternidade Escola da UFRJ, and D’Or Institute for Research & Education, Rio de Janeiro, RJ, Brazil.
Provenance and peer review Not commissioned; externally peer reviewed.
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