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Aseptic meningitis associated with routine infant immunisation visits that include the group B meningococcal vaccine, 4CMenB
  1. Andrew Riordan1,
  2. Shamez N Ladhani2
  1. 1 Department of Infectious Diseases and Immunology, Alder Hey Childrens NHS Foundation Trust, Liverpool, UK
  2. 2 Immunisation and Countermeasures Department, Public Health England Colindale, London, UK
  1. Correspondence to Dr Shamez N Ladhani, Immunisation and Countermeasures Division, Public Health England, London NW9 5EQ, UK; DrShamez{at}

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We were interested to read the report by So et al 1 describing an infant who was unwell prior to receiving their first set of primary immunisations (including the four-component meningococcal B vaccine 4CMenB; Bexsero; GSK Biologicals) and was subsequently diagnosed with meningococcal group W meningitis shortly after vaccination. The authors highlight factors that would not have been consistent with an adverse event following immunisation (AEFI), namely the onset of fever prior to immunisation and the presentation with focal seizures, which is rare following 4CMenB vaccination, even when administered concurrently with routine immunisations.2 Such a …

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  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.