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Not uncommonly, the issue of the generalisability or representativeness of a study population to the ’real world' is raised. There are some pretty big issues here, not least the idea that studies are undertaken in an unreal world, where troubles melt like chimney tops and sail above your lemon drops. Avoiding those sorts of mangled lyrics though—what’s the challenge of ‘representativeness’?
If we simply and split in into the patients, and the interventions, we can think about the threats to using study data to inform practice. As for patients—we …
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