You are here

Article Text

Article menu
Download PDFPDF
Miscellanea
Archivist
Three modulator drugs are better than two in cystic fibrosis

https://doi.org/10.1136/archdischild-2018-316579

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    The development of radically new treatments for cystic fibrosis (CF) proceeds apace. In February 2018 Archivist reported on trials of double-modulator therapies (tezacaftor-ivacaftor) that produced modest benefits (doi:10.1136/archdischild-2017–3 14 602). Adding a third agent could, in theory, further enhance the intracellular functioning of the defective CFTR protein by binding to different sites on the molecule, particularly in those with the most common Phe508del mutation.

    Two such agents which showed promise in vitro were used in …

    View Full Text

    Footnotes

    • Patient consent for publication Not required.

    • Competing interests None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.