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We previously showed that intravenous paracetamol as primary analgesic after major non-cardiac (laparotomy or thoracotomy) surgery in infants <1 year of age reduces postoperative morphine consumption by 66% when compared with continuous intravenous morphine.1 Implementation of trial results is often challenging due to barriers such as low acceptance by healthcare professionals, lack of motivation and lack of awareness.2 Given the morphine-sparing effects of intravenous paracetamol we implemented intravenous paracetamol into our hospital’s clinical practice. We now present the real-life efficacy of intravenous paracetamol for this indication and adherence to the new postoperative pain protocol.
The setting for this observational study was a tertiary care paediatric intensive care unit (PICU). In our new postoperative pain protocol, starting from January 2014, intravenous paracetamol is the primary analgesic (figure …
Contributors MAB: data collection and writing of the first draft of manuscript. EI: study design, statistical analysis and writing of the first draft of manuscript. TdL: data verification and contribution to the final manuscript. JvR: statistical analysis and contribution to the final manuscript. DT and MvD: study design and contribution to the final manuscript. SNdW: study design, coordination and contribution to the final manuscript.
Competing interests None declared.
Patient consent Not required.
Ethics approval METC Erasmus MC.
Provenance and peer review Not commissioned; internally peer reviewed.
Data sharing statement Data are provided on request.