Article Text

PDF
Question 2: In children with Marfan’s should we beta block from point of diagnosis?
  1. Maria Tennyson
  1. Correspondence to Miss Maria Tennyson, School of Clinical Medicine, University of Cambridge, Cambridge, UK; mt607{at}cam.ac.uk

Statistics from Altmetric.com

Scenario

A 10-year-old boy seen in genetics clinic following a recent diagnosis of Marfan’s syndrome. The geneticist mentioned the use of prophylactic beta-blockers to reduce the risk of aortic dilatation. The boy’s mother is concerned about the prospect of taking daily medication from an early age and asks if this is necessary.

Structured clinical question

’Should beta-blockers (intervention) be commenced in all paediatric Marfan’s patients (patient) to prevent aortic dilation (outcome)?

Search

The Cochrane Library with the search terms ‘Marfan’s’ and ‘beta blockers’ yielded two reviews (one relevant) and three trials (two relevant).

EMBASE (All Resources) (Ovid)(Marfan’s and (beta blocker or beta blockade or beta-blocker or beta-blockers) and (children or adolescent or paediatrics or adolescents or kids or child or paeds)).af.

Four hundred and sixty-five references were identified. Abstracts were screened for suitability. Studies in an exclusively adult population, those looking only at the biophysical properties of the aorta and those in animal models were excluded. This yielded 10 further papers.

PubMed(MeSH ((Marfan’s) AND (beta blocker OR beta blocker OR beta blockade OR beta-blocker)) AND (children OR adolescent OR paediatrics OR adolescents OR kids OR child OR paeds).

Sixteen references …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles