Article Text

Download PDFPDF
4CMenB and post-immunisation fever: an emerging hot topic
  1. Maya Lamoudi,
  2. Faye Baxter,
  3. Amarpal Bilkhu,
  4. Claire Hathorn
  1. Royal Hospital for Sick Children, Edinburgh, UK
  1. Correspondence to Dr Claire Hathorn, Royal Hospital for Sick Children, Edinburgh EH9 1LF, UK; Claire.Hathorn{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

We read with interest recently published articles regarding fever post-immunisation following the introduction of the four-component meningococcal B vaccine (4CMenB).1–3

In retrospective1 and prospective2 audits, Nainani et al (n=38) and Kapur et al (n=35) demonstrated significant increases in emergency department (ED) attendances (0.8% of the local vaccinated population2), investigations (venepuncture in 38%1 and 62%,2 lumbar puncture (LP) in 22%1 and 17%2) and hospitalisations (72%1 and 51%2 (for post-immunisation fever). Murdoch et al’s3 self-controlled case series estimated an additional 1440 hospital admissions per year in the UK following 4CMenB introduction.

We conducted a retrospective audit of infants presented to the ED at …

View Full Text


  • Contributors AB, FB and CH designed the audit. AB, FB and ML collected the data. ML drafted the manuscript. All other authors contributed to revisions and agreed with the final manuscript.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.