Participant a boy whose respiratory condition was evaluated during almost 14 years period. His critical point started from age of six months, when exhibited recurrent wheezing. At age of two years was diagnosed with asthma and at age of four years exhibited a positive reaction on a TB (tuberculosis) skin test, while clinical features and medical analysis did not confirm severe cardiac and pulmonary disease. During his childhood he presented several respiratory infections and 2–3 recurrent asthma attacks per year. At 12 years age he exhibited an exacerbation of hypertension blood pressure and computed tomography showed a cardiac malformation, button aorta has a right footprint on the trachea, the trail descending aorta being partially right side. Parent of investigated subject agreed and signed an informed consent. Several clinical and laboratory evaluations each three month for each year with adequate protocols have been performed.Regularly control of immunoglobulin levels IgE, IgA, IgG and IgM was done. A specific anti-asthma medication during early years till now (LT inhibitors, corticosteroids CIS agonists),and immunomodulatory treatment (Luivac, Thym-Uvocal),vitamin therapy (Ca, D3, Magne B6) and CoQ10 have been administrated.