Introduction Monitoring the success of treatment with inhaled corticosteroid fluticasone propionate type comparing with inbibitor of leukotriene, montelukast in preschool children is an everyday topic. Control of chronic obstructive pulmonary disease is one of the most important issues today in paediatrics, especially in paediatric pulmonology.

Objective Improving control of chronic obstructive pulmonary disease in children at an early stage of the disease from twelve months by the age of four.

Methods The study included all children between the ages of twelve months to four years of age with obstructive bronchitis in the dispensary Centre Sarajevo. Total 360 children divided into three age groups and the same number use two different drug fluticasone propionate inhaled or montelukast in the form of granules in sixty sick children in each age subgroup. Authors were excluded children with antibiotic therapy in this reasearch.

Results The drug of fluticasone propionate proved slightly more effective in controlling these diseases in the percentage of 96% relative to other drug montelukast with 93% of the total of all age groups. No significant differences in age groups and in relation to sex of children.

Conclusion Both drug and fluticasone propionate and montelukast have shown excellent disease control but can not be given to any advantage in monitoring chronic obstructive pulmonary disease in preschool children.