Introduction The use of probiotics in paediatric practice is very common. However scheme and course of action is different from the paediatrician to paediatrician, however, and on a case-by-case basis. It is usually given with oral antibiotics.

Objective Establish monitoring the use of antibiotics with different types of probiotics.

Methods A control study of children using antibiotics for 1000 cases without probiotics and 1000 cases with a probiotic. It was used as a reference antibiotic cefixime and probiotics four different types in equal numbers. The study period is two years from the beginning of 2015 until the end of 2016 in the primary pre-school clinic in Sarajevo.

Results It showed the significant success of antibiotic therapy of cefixime with probiotics compared to antibiotic therapy without probiotics. The percentage of complications of diarrhoea was 7.9% (79) without probiotics while with probiotics the percentage of 2.7% (27). No differences between the discontinuous administration of probiotics (at the beginning and end of the treatment) of a continuous time for taking any antibiotic therapy.

Conclusion It is very useful taking probiotics with antibiotics in children but it can be recommended. Continual use has no advantages over discontinual use of probiotics with antibiotics.