BACKGROUND Mother to baby transmission is well documented for hepatitis B virus (HBV) and the human immunodeficiency virus (HIV). Although are case reports of vertical transmission of hepatitis C virus (HCV), it remains uncertain to what extent infected mother transmit this virus to their infants. Hepatitis C virus (HCV) infection is characterised by persistent viraemia and the virus is a major cause of liver disease including cirrhosis and hepatocellular carcinoma. There are also major clinical, virologic, immunologic and also the effect of CMV on the progression of HIV disease at a newborn.

Methods This work presents the case of a premature newborn (33 weeks), extracted by caesarean section, partially investigated pregnancy, W=2360 g, Apgar score 8. The newborn was initially considered exposed HIV but quickly after tests he was diagnosed as symptomatic HIV – C1.

At short time after birth present general condition modified and after blood tests he was diagnosed also with hepatitis B, hepatitis C and CMV virus.

Results AND ConclutionS Was started therapy with lamivudine and zidovudine. What you will do in this case? How you will manage such a difficult case? What you will choose as a third antiretroviral therapy?

HCV is vertically transmitted from mother to infant and the risk of transmission is correlated with titer of HCV RNA at the mother.

CMV co-infection was correlated with rapid progression of HIV disease and with devastating early central nervous system disease.