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P258 Bloodstream infections caused by serratia marcescens in paediatric patients
  1. Tuğba Erat1,
  2. Aysun Yahši1,
  3. Tuğ;çe Tural Kara1,
  4. Halil Özdemir1,
  5. Ebru Azapağasi2,
  6. Oktay Perk2,
  7. Tanil Kendirli2,
  8. Elif Ünal Ince3,
  9. Begüm Atasay4,
  10. Emel Ünal3,
  11. Ergin Çiftçi1,
  12. Erdal Ince1
  1. 1Ankara University Faculty of Medicine, Department of Paediatric Infectious Diseases, Ankara, Turkey
  2. 2Ankara University Faculty of Medicine, Department of Paediatric Intensive Care Unit, Ankara, Turkey
  3. 3Ankara University Faculty of Medicine, Paediatric Haematology and Oncology, Ankara, Turkey
  4. 4Ankara University Faculty of Medicine, Neonatal Intensive Care Unit, Ankara, Turkey


We reported a retrospective cohort study was designed to investigate features of S. marcescens outbreak in a children hospital, Turkey. S. marcescens was isolated from the blood culture of 45 patient. Their demographic and clinical features, results of antimicrobial susceptibility testing and 28 day all cause mortality were recorded. The most common underlying condition was ma­lignancy (26.9%). The median length of hospital stay was 42,7±41.4 (3–171) days. Forty-three of the patients had CVCs during the BSI episodes. Primary BSI was diagnosed in 24 (53.3%) episodes, catheter related BSI were considered in 21 episodes. The median duration of CVC prior to catheter related BSI 46,02±50,96 (1-200) days. 24 catheter (55.8%) was removed. Four patients (8.9%) died during the bacteriemia episode. Fatal group laboratory findings; median WBC, median serum CRP and albumin level were higher than non-fatal group. 57.8% isolates of S. marcescens produced ESBL and 40% isolates produced carbapenemases. We classified this isolates non-MDR (42.2%), MDR (31.1%), XDR (24.4%) and PDR (2.2%). The most common regimes received for XDR isolates were meropenem infusion, amikacin, levofloxacin and tigecycline. Since S. marcescens isolates are intrinsically resistant to polymyxins, and producting ESBL, carbapenemase among these pathogens is a cause of great concern. Mortality reduced by continuous-infusion meropenem and removed catheters early.

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