Background and aims Cystic Fibrosis represents the most frequent monogenic autosomal recessive disease in Caucasians. Among multiple systemic determination, the pancreatic function is affected, with primordial exocrine dysfunction and second endocrine disorder. Acute pancreatitis is a rare complication in CF, rapid diagnosis allowing selection of patients for closer monitoring for recurrent events.

Method 5 year retrospective study, conducted in INSMC ‘Alessandrescu Rusescu’, Bucharest. All charts of our CF patients were revised and 48 patients aged>3 years were included. Acute clinical manifestation like : violent abdominal pain and vomiting associated with high amylase levels above 170ui/L, serum glucose, ALT, AST and BMI.

Results 3 patients were diagnosed with acute pancreatitis, with a frequency of 6,25%. None of the patients associated high glucose serum levels nor high AST or ALT. BMI was 17,3–18,07 kg/m². One patient presented a recurrent event during the 5 year study. In 2 patients we found low compliance for PERT and in 1 patient Campylobacter Pylori acute gastroenteritis was associated.

Conclusions We identified a higher frequency of acute pancreatitis among our patients ( 6,25% compared with 3,5% described in general population) possibly determined by low treatment compliance ( PERT and nutritional recommendation) and associated with digestive illnesses.