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Abstract
Intrauterine growth retardation (IUGR) is prevalent in various regions with a frequency of 4% to 15%. Mechanisms of its development remain poorly understood.
Objective to evaluate the level of GH and IGF II in mothers and their newborn children with different variants of intrauterine growth.
Materials and methods 175 pairs of mother – newborn child were studied. In the 1 st group there were 46 children ‘Light for gestation age’ (P05.0 according to the ICD-10), the 2-nd ‘Small for gestation age’ (P05.1), control – 45 children without trophic disorders.
Results Infants of the 1 st group had a level of GH 21,28 ng/ml, compared with the 2-nd which was 27.3% lower. Newborns of the 1 st group had the lowest level of IGF II – 136,56 mg/ml, in the 2-nd it was 179,65, and 191,82 in control. GH level of mothers in the 2-nd group was 0.91 ng/ml, which was less than in the 1 st group by 28.9%, and less than control by 30.5%. In each group compared rates of hormones depending on the degree of IUGR. In infants with birth weight less than P3 concentration of GH in their mothers was 1.19 ng/ml, the level of IGF II was 360,13 mg/ml. In infants P3-10, the level of GH of their mothers was higher by 10,5% (to 1.33 ng/ml), and IGF II – 27,2% (494,5 mg/ml) than in group with birth weight less than P3.
Thus GH and IGH II have important role in development of IUGR