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Question 1: Is a low-bacterial diet helpful in preventing infection in immunosuppressed children?
  1. Amanda J Friend1,
  2. Sarah Maltby2
  1. 1Department of Paediatrics, Leeds General Infirmary, Leeds, UK
  2. 2Department of Paediatric Rheumatology, Leeds General Infirmary, Leeds, UK
  1. Correspondence to Dr Amanda J Friend, Department of Paediatrics, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK; amanda.friend{at}

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A child aged 7 years is being discharged home on oral immunosuppressants following a renal transplant. You routinely advise children in this situation to avoid foods such as unpasteurised cheeses and fresh pastries. You wonder whether this low-bacterial diet will actually prevent infection.

Structured clinical question

In a child on immunosuppressive therapy (patient), does adherence to a low-bacterial diet (intervention) compared with normal, unrestricted diet (control) lead to reduced incidence of infection (outcome) and whether these dietary restrictions lead to reduced quality of life and/or are acceptable to the patients (secondary outcomes)?

Search date 26 September 2016

We searched the Cochrane library, PubMed, Web of Science, Scopus, Embase/OVID and CINAHL for the following terms: (‘low bacterial diet’ OR ‘low bacteria diet’ OR ‘low microbial diet’) AND (immunosuppres* OR neutropeni*)

AND (sepsis OR infection). We found 30 individual articles (77 including duplicates), of which …

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  • Twitter Follow Amanda Friend @the_learnaholic

  • Contributors AJF carried out the literature search. AJF and SM reviewed the results and decided on papers to be included/excluded. AJF wrote the manuscript which was then reviewed by SM.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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